Comparative evaluation of regulatory health risk assessment frameworks for fluoride-contaminated environments.

• Ahada, C. P., & Suthar, S. (2019). Assessment of human health risk associated with high groundwater fluoride intake in southern districts of Punjab, India. Exposure and Health, 11(4), 267–275.

  Article  CAS  Google Scholar

• Ahmad, M. N., Zia, A., van den Berg, L., Ahmad, Y., Mahmood, R., Dawar, K. M., Alam, S. S., Riaz, M., & Ashmore, M. (2022). Effects of soil fluoride pollution on wheat growth and biomass production, leaf injury index, powdery mildew infestation and trace metal uptake. Environmental Pollution, 298, Article 118820.

  Article  CAS  Google Scholar

• Ahn, Y., Pandi, K., Cho, D.-W., & Choi, J. (2021). Feasibility of soil washing agents to remove fluoride and risk assessment of fluoride-contaminated soils. Journal of Soils and Sediments, 21, 2770–2777.

  Article  CAS  Google Scholar

• Ali, S., Fakhri, Y., Golbini, M., Thakur, S. K., Alinejad, A., Parseh, I., Shekhar, S., & Bhattacharya, P. (2019). Concentration of fluoride in groundwater of India: A systematic review, meta-analysis and risk assessment. Groundwater for Sustainable Development, 9, Article 100224.

  Article  Google Scholar

• Ayub, M., Javed, H., Rashid, A., Khan, W. H., Javed, A., Sardar, T., Shah, G. M., Ahmad, A., Rinklebe, J., & Ahmad, P. (2024). Hydrogeochemical properties, source provenance, distribution, and health risk of high fluoride groundwater: Geochemical control, and source apportionment. Environmental Pollution, 362, Article 125000.

  Article  CAS  Google Scholar

• Bhattacharya, P., Samal, A. C., Banerjee, S., Pyne, J., & Santra, S. C. (2017). Assessment of potential health risk of fluoride consumption through rice, pulses, and vegetables in addition to consumption of fluoride-contaminated drinking water of West Bengal, India. Environmental Science and Pollution Research, 24, 20300–20314.

  Article  CAS  Google Scholar

• Bilotta, G. S., Milner, A. M., & Boyd, I. (2014). On the use of systematic reviews to inform environmental policies. Environmental Science & Policy, 42, 67–77.

  Article  Google Scholar

• Braatz, H. M., Jung, M., Moon, S., & Park, J. (2019). Human risk assessment of soil contaminated with heavy metal by waste reclaimed in railway maintenance site. Journal of the Korea Organic Resources Recycling Association, 27(3), 63–74.

  Google Scholar

• Chandra, G. V., & Ghosh, P. K. (2024). Groundwater quality in high-sulfur coal mining region of India: Spatial distribution, source control, and health risk assessment. Journal of Environmental Management, 368, Article 122281.

  Article  Google Scholar

• Chavoshi, E., Afyuni, M., Hajabbasi, M., Khoshgoftarmanesh, A., Abbaspour, K., Shariatmadari, H., & Mirghafari, N. (2011). Health risk assessment of fluoride exposure in soil, plants, and water at Isfahan, Iran. Human and Ecological Risk Assessment: An International Journal, 17(2), 414–430.

  Article  CAS  Google Scholar

• Cho, D.-W., Jeon, B.-H., Jeong, Y., Nam, I.-H., Choi, U.-K., Kumar, R., & Song, H. (2016). Synthesis of hydrous zirconium oxide-impregnated chitosan beads and their application for removal of fluoride and lead. Applied Surface Science, 372, 13–19.

  Article  CAS  Google Scholar

• De, A., Ghosh, S., Dey, A., Islam, K. H., Maji, K., Mandal, J., Das, B. C., & Roychowdhury, T. (2024). Assessing groundwater fluoride contamination scenario in West Bengal, India: A combined approach using meta-analysis, current research, and health risk evaluation. Groundwater for Sustainable Development, 26, Article 101286. https://doi.org/10.1016/j.gsd.2024.101286

  Article  Google Scholar

• Edward, E., Moirana, R., Mwema, M. F., & Mtei, K. (2025). Assessment of water-soluble fluoride contamination in cultivated and uncultivated soils along the slopes of Mount Meru, Tanzania. Environmental Monitoring and Assessment, 197(12), 1–9.

  Article  Google Scholar

• EPA, U. (2001). Supplemental guidance for developing soil screening levels for superfund sites. Peer Review Draft, OSWER, 9355, 4–24.

• EPA, A. (2004). Risk assessment guidance for superfund. Volume I: human health evaluation manual (Part E, supplemental guidance for dermal risk assessment).

• He, L., Tu, C., He, S., Long, J., Sun, Y., Sun, Y., & Lin, C. (2021). Fluorine enrichment of vegetables and soil around an abandoned aluminium plant and its risk to human health. Environmental Geochemistry and Health, 43, 1137–1154.

  Article  CAS  Google Scholar

• Jagtap, S., Yenkie, M. K., Labhsetwar, N., & Rayalu, S. (2012). Fluoride in drinking water and defluoridation of water. Chemical Reviews, 112(4), 2454–2466.

  Article  CAS  Google Scholar

• Jeong, S.-W. (2024). Derivation of soil fluorine standards based on a human health risk assessment method. Journal of Soil and Groundwater Environment, 29(3), 14–22.

  Google Scholar

• Ji, C. H., Lee, S. H., Bae, G. S., & Kim, H. W. (2024). Balancing environmental safety and economic feasibility: A review of soil fluorine management strategies in South Korea. Sustainability, 16(19), Article 8391.

  Article  CAS  Google Scholar

• Kim, D.-H., Jeon, C.-S., Baek, K., Ko, S.-H., & Yang, J.-S. (2009). Electrokinetic remediation of fluorine-contaminated soil: Conditioning of anolyte. Journal of Hazardous Materials, 161(1), 565–569.

  Article  CAS  Google Scholar

• Kumar, E., Bhatnagar, A., Ji, M., Jung, W., Lee, S.-H., Kim, S.-J., Lee, G., Song, H., Choi, J.-Y., Yang, J.-S., & Jeon, B.-H. (2009). Defluoridation from aqueous solutions by granular ferric hydroxide (GFH). Water Research, 43(2), 490–498.

  Article  CAS  Google Scholar

• Kumar, P., Kumar, M., Barnawi, A. B., Maurya, P., Singh, S., Shah, D., Yadav, V. K., Kumar, A., Kumar, R., Yadav, K. K., Gacem, A., Ahmad, A., Patel, A., Alreshidi, M. A., Singh, V., Yaseen, Z. M., Cabral-Pinto, M. M. S., Vinayak, V., & Wanale, S. G. (2024). A review on fluoride contamination in groundwater and human health implications and its remediation: A sustainable approaches. Environmental Toxicology and Pharmacology, 106, Article 104356. https://doi.org/10.1016/j.etap.2023.104356

  Article  CAS  Google Scholar

• Li, Y., Wang, S., Nan, Z., Zang, F., Sun, H., Zhang, Q., Huang, W., & Bao, L. (2019). Accumulation, fractionation and health risk assessment of fluoride and heavy metals in soil-crop systems in Northwest China. Science of the Total Environment, 663, 307–314.

  Article  CAS  Google Scholar

• Lu, M.-Y., Liu, Y., Liu, G.-J., Li, Y.-L., Xu, J.-Z., & Wang, G.-Y. (2023). Spatial distribution characteristics and prediction of fluorine concentration in groundwater based on driving factors analysis. Science of the Total Environment, 857, Article 159415.

  Article  CAS  Google Scholar

• MOE, 2018, Guideline for Risk Assessment of Soil Contaminants (No. 2018–184), issued December 27, 2018 (Ministry of Environment, Republic of Korea); https://www.law.go.kr/admRulInfoP.do?admRulSeq=2100000168975

• Mridha, D., Priyadarshni, P., Bhaskar, K., Gaurav, A., De, A., Das, A., Joardar, M., Chowdhury, N. R., & Roychowdhury, T. (2021). Fluoride exposure and its potential health risk assessment in drinking water and staple food in the population from fluoride endemic regions of Bihar, India. Groundwater for Sustainable Development, 13, Article 100558.

  Article  Google Scholar

• Prabhu, S. M., Chuaicham, C., Park, C. M., Jeon, B.-H., & Sasaki, K. (2021). Synthesis and characterization of defective UiO-66 for efficient co-immobilization of arsenate and fluoride from single/binary solutions. Environmental Pollution, 278, Article 116841.

  Article  CAS  Google Scholar

• Prabhu, S. M., Yusuf, M., Ahn, Y., Park, H. B., Choi, J., Amin, M. A., Yadav, K. K., & Jeon, B.-H. (2023). Fluoride occurrence in environment, regulations, and remediation methods for soil: A comprehensive review. Chemosphere, 324, Article 138334.

  Article  Google Scholar

• Rango, T., Vengosh, A., Jeuland, M., Tekle-Haimanot, R., Weinthal, E., Kravchenko, J., Paul, C., & McCornick, P. (2014). Fluoride exposure from groundwater as reflected by urinary fluoride and children’s dental fluorosis in the Main Ethiopian Rift Valley. Science of the Total Environment, 496, 188–197.

  Article  CAS  Google Scholar

• Srivastava, S., & Flora, S. (2020). Fluoride in drinking water and skeletal fluorosis: A review of the global impact. Current Environmental Health Reports, 7(2), 140–146.

  Article  CAS  Google Scholar

• Su, C., Ge, W., Xie, X., Guo, Z., Luo, Z., Gan, Y., Xiao, Z., Gao, Y., & Yang, Y. (2025). Prediction and controlling factors of high-fluoride groundwater in the Yellow River Basin based on machine learning model. Groundwater for Sustainable Development, 30, Article 101458.

  Article  Google Scholar

• U.S. Environmental Protection Agency (U.S. EPA). (1989). Risk Assessment Guidance for Superfund, Volume I: Human Health Evaluation Manual (Part A), Interim Final. EPA/540/1–89/002. Washington, DC.

• Wu, S., Wang, Y., Iqbal, M., Mehmood, K., Li, Y., Tang, Z., & Zhang, H. (2022). Challenges of fluoride pollution in environment: Mechanisms and pathological significance of toxicity–a review. Environmental Pollution, 304, Article 119241.

  Article  CAS  Google Scholar

• Yang, Y., Zhang, R., Zhang, F., & Li, Y. (2023). Spatial–temporal variation and health risk assessment of fluoride in surface water in the Tibetan Plateau. Exposure and Health, 15(2), 281–297.

  Article  CAS  Google Scholar

• Yin, N., Li, Y., Yang, Y., Fan, C., Li, Y., Du, X., Sun, G., & Cui, Y. (2021). Human health risk assessment in aluminium smelting site: Soil fluoride bioaccessibility and relevant mechanism in simulated gastrointestinal tract. Journal of Hazardous Materials, 416, Article 125899.

  Article  CAS  Google Scholar

• Yu, Y.-Q., Luo, H.-Q., & Yang, J.-Y. (2022). Health risk of fluorine in soil from a phosphorus industrial area based on the in-vitro oral, inhalation, and dermal bioaccessibility. Chemosphere, 294, Article 133714.

  Article  CAS  Google Scholar

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