Research Studies
Study Tracker
Effect of fluoride on oxidative stress and biochemical markers of bone turnover in postmenopausal women
| Fluoride | Gondu AS, Naidu MD. | 46(4):208–211.
Postmenopausal Age Bones/Joints Mechanisms of Cellular Toxicity Oxidative Stress Epidemiology Human Study
View PDF

Abstract

The present study was conducted on 42 postmenopausal women subjects in Vailapally village, Nalgonda district, Andhra Pradesh, India, an endemic fluorotic area (water fluoride >4 ppm) and 34 postmenopausal women of nonfluorotic villages (water fluoride <0.4 ppm) of the Nalgonda area. The age group of the recruited subjects was 48–58 years and their years since menopause (YSM) was <10 years. Serum levels of fluoride (F), total alkaline phosphatase (ALP), tartarate resistant acid phosphatase-5b (TRAP-5b), catalase (CAT), glutathione-S-transferase (GST) and malondialdehyde (MDA) were estimated for bone mineral antioxidant and lipid peroxidation status. Significantly increased bone turnover markers ALP, TRAP-5b (p<0.01), and oxidative stress were observed with decreased levels of CAT and GST (p<0.01) activity in postmenopausal women residing in the fluorotic village. Significantly elevated levels of MDA (p<0.01) in these women compared to those in the nonfluorotic village indicated an increase in lipid peroxidation under fluoride stress.