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Effect of sodium fluoride in maternal and offspring rats and its amelioration
| Asian Pacific Journal of Reproduction | Panchal S, Verma RJ. | 3(1):71-76.
Animal offspring Anti-Oxidants Bones/Joints Calcium Fetal Toxicity & Teratology Mechanisms of Cellular Toxicity Oxidative Stress Review
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Abstract

High fluoride content is known to cause dental and skeletal abnormalities. In addition, present review indicates that sodium fluoride consumption caused increased number of resorptions and dead foetuses. Various skeletal anomalies such as wavy ribs, presence of 14th ribs, lacking 6th sternebrae and incomplete ossification of skull occur. All these changes could be due to oxidative stress caused by fluoride consumption. Fluoride-induced changes could be successfully ameliorated by cotreatment with vitamins and calcium.