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Evaluation of fluoride release from commercially available fluoride varnishes.
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Journal of the American Dental Association
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Castillo JL, Milgrom P, Kharasch E, Izutsu K, Fey M.
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132(10):P1389-1392.
References
Murray JJ
Winter GB
Hurst CP
Duraphat fluoride varnish: a 2-year clinical trial in 5-year-old children.
Br Dent J. 1977; 143: 11-17
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Holm AK
Effect of fluoride varnish (Duraphat) in preschool children.
Community Dent Oral Epidemiol. 1979; 7: 241-245
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Scopus (65)
PubMed
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Petersson LG
Arthursson L
Ostberg
Abstract
Background
The authors conducted a study to evaluate the fluoride released from two fluoride varnishes: Duraphat (Colgate-Palmolive Co., New York) and Duraflor (Pharmascience Inc., Montreal). Fluoride-release information for these commercially available dental products has not been available to clinicians treating children at risk of developing dental caries.
Methods
The authors painted enamel slabs from primary molar teeth with 30 milligrams of two varnishes: nine samples received Duraphat, nine received Duraflor and five samples served as controls. The samples were immersed in buffered calcium phosphate solution (pH, 6.0) to simulate the oral environment, and the amount of fluoride released was measured weekly for six months.
Results
From week 4 to the end of the study, Duraphat released significantly more fluoride than Duraflor. Duraflor continued releasing fluoride until week 19, while Duraphat released fluoride until week 28. The authors found greater variability in the release of fluoride from the Duraflor samples than from the Duraphat samples. Two-thirds of the fluoride was released from both products by the end of the study.
Conclusions
Both varnishes released fluoride for five to six months. However, the two products exhibited differences in their release kinetics.
Clinical Implications
These findings show that either of the fluoride varnishes may maintain a high level of fluoride in plaque fluid around primary teeth over a long period, but that the availability of fluoride may vary among tubes of the same product and between the two products themselves.
*Original abstract online at https://jada.ada.org/article/S0002-8177(14)63720-X/fulltext#relatedArticles
References
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Duraphat fluoride varnish: a 2-year clinical trial in 5-year-old children.
Br Dent J. 1977; 143: 11-17
-
Effect of fluoride varnish (Duraphat) in preschool children.
Community Dent Oral Epidemiol. 1979; 7: 241-245
-
Caries-inhibiting effects of different modes of Duraphat varnish reapplication: a 3-year radiographic study.
Caries Res. 1991; 25: 70-73
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Third-party reimbursement and use of fluoride varnish in adults among general dentists in Washington State.
JADA. 2000; 131: 961-968
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Effect of fluoride varnishes and Nuva-Seal resin treatment on the formation of artificial carious lesions.
Caries Res. 1981; 15: 250-255
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The inhibition of demineralization of human enamel after fluoride varnish application as a function of the fluoride content: an in vitro study under constant composition demineralizing conditions.
J Biol Buccale. 1986; 14: 133-138
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Effect of fluoride varnish and solution on enamel erosion in vitro.
Caries Res. 1994; 28: 227-232
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Effects of a sodium fluoride solution and a varnish with different fluoride concentrations on enamel remineralization in vitro.
Scand J Dent Res. 1988; 96: 304-309
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The science and practice of caries prevention.
JADA. 2000; 131: 887-899
-
Differences in pH fall, phosphorous content and dissolution of enamel in layers of the oral bacterium Streptococcus mutans deposited in vitro on bovine enamel granules with and without fluoride varnish.
Arch Oral Biol. 1982; 27: 1003-1006
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Effect of a fluoride-containing varnish on Streptococcus mutans in plaque and saliva.
Scand J Dent Res. 1982; 90: 423-428
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Effect of whole saliva components on enamel demineralization in vitro.
Crit Rev Oral Biol Med. 1993; 4: 357-362
Article Info
Footnotes
The study was supported by the Orthodontic Memorial Fund and grant DE09743 to the Regional Clinical Dental Research Center at the University of Washington, Seattle, from the National Institute of Dental and Craniofacial Research, National Institutes of Health.
The authors acknowledge the assistance of Prof. John D. Featherstone, University of California, San Francisco.
Identification
Copyright
© 2001 American Dental Association. Published by Elsevier Inc. All rights reserved.