Fluoride + aluminum induced toxicity in mice testis witih giant cells and its reversal by vitamin C

Abstract

Administration of sodium fluoride (NaF, 10 mg/kg bw) together with aluminium chloride (AlCl3, 200 mg/kg bw) to adult male mice for 30 days resulted in structural alterations in the testis with formation of giant cells. These changes along with lower protein levels affected spermatogenesis. Steroidogenesis was also altered since the activities of 3?- and 17?-hydroxysteroid dehydrogenases were inhibited with accumulation of cholesterol. Although withdrawal of treatment for 30 days resulted in some recovery, administration of vitamin C along with the toxicants produced significant recovery.