Fluoride impairment of glucose utilization: nature of effect in rats during and after continuous NaF infusion.

Abstract

Intravenous infusion of 6 mg of fluoride/kg/hr for 3 hr caused a sharp decrease in formation of respiratory ¹⁴CO₂ from [¹⁴C]glucose, regardless of position of the label. Oxidation of [1-¹⁴C]fructose was not impaired, indicating that triose metabolism was not hindered; this information, along with the similarity in depression of metabolism of all labels indicated that glycolysis was not impaired. Glycogen deposition was decreased. The data suggest that the interference caused by fluoride at the observed concentrations is located at or prior to phosphorylation of glucose.