Urinary tract calculi obtained from 25 patients residing in an endemic fluorotic area revealed a significantly higher fluoride content compared to calculi from 25 persons from a nonendemic area. However the difference in their calcium and phosphate content was not significant. Twenty-four hour urinary fluoride excretion was significantly higher in 10 fluorotic patients than in 10 controls. The incidence of urinary tract calculi was elevated in most of the fluorotic districts of Punjab.