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Multifocal nodular periostitis associated with prolonged voriconazole therapy in a lung transplant recipient.
| Journal of Clinical Rheumatology | Ayub A, Kenney CV, McKiernan FE. | 17(2):73-5.
Periostitis deformans Voriconazole Bones/Joints Pharmaceuticals Sources of Exposure Case Report Human Study

Abstract

We report a case of painful, nodular periostitis in a lung transplant recipient on long-term voriconazole therapy. Symptoms, signs, and laboratory abnormalities resolved quickly after drug withdrawal. The presentation more closely resembles periostitis deformans than hypertrophic osteoarthropathy, suggesting that the fluoride moiety of voriconazole may be pathogenic for this condition. Clinicians should be aware of this association.