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Necessity to Pay Attention to the Effects of Low Fluoride on Human Health: an Overview of Skeletal and Non-skeletal Damages in Epidemiologic Investigations and Laboratory Studies.
| Biological Trace Element Research | Zhou J, Sun D, Wei W. | [Epub ahead of print]
Heart Immune System Kidney Liver Reproductive Toxicity Thyroid Gland Review
References Zhou G, Yang L, Luo C, Liu H, Li P, Cui Y, Liu L, Yu X, Zeng Q, Chen J, Zhao Q, Dong L, Niu Q, Zhang S, Wang A (2019) Low-to-moderate fluoride exposure, relative mitochondrial DNA levels, and dental fluorosis in Chinese children. Environ Int 127:70–77. https://doi.org/10.1016/j.envint.2019.03.033 CAS  Article  Google Scholar Sreemanta P, Depanwita S (2017) The genetic influence in fluorosis. Environ Toxicol Phar 56:157–162. https://doi.org/10.1016/j.etap.

Abstract

Due to the implementation of water improvement and fluoride reduction plans supported by central and local governments in recent years, areas with high fluoride exposure are being gradually decreased. Therefore, it is of practical importance to study the effect of low fluoride on human health. Epidemiologic investigations and in vivo and in vitro studies based on low fluoride have also confirmed that fluoride not only causes skeletal damage, such as dental fluorosis, but also causes non-skeletal damage involving the cardiovascular system, nervous system, hepatic and renal function, reproductive system, thyroid function, blood glucose homeostasis, and the immune system. This article summarizes the effects of low fluoride on human and animal skeletal and non-skeletal systems. A preliminary exploration of corresponding mechanisms that will help to fully understand the harm of low fluoride on human health was undertaken to provide the basis for establishing new water fluoride standards and help to implement individual guidance.

*Original abstract online at https://link.springer.com/article/10.1007/s12011-022-03302-7

Excerpt:

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Author information

Authors and Affiliations

  1. Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, Heilongjiang Province, China

    Jing Zhou, Dianjun Sun & Wei Wei

  2. National Health Commission, Key Laboratory of Etiology and Epidemiology, Harbin Medical University (23618504), Harbin, 150081, Heilongjiang Province, China

    Jing Zhou, Dianjun Sun & Wei Wei

  3. Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health, Harbin Medical University, 150081, Harbin, Heilongjiang Province, China

    Jing Zhou, Dianjun Sun & Wei Wei

Contributions

Jing Zhou, Wei Wei, and Dianjun Sun analyzed the references, Jing Zhou wrote the article, and Wei Wei and Dianjun Sun modified the article.

Correspondence to Wei Wei.

*Original abstract online at https://link.springer.com/article/10.1007/s12011-022-03302-7