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Role des inhibiteurs enzymatiques dans l'etiologie du mongolisme
| Annali di Neuropsichiatria e Psicoanalisi | Rapaport I. | 4(1):13-20.
Downs Syndrome Enzymes Fetal Toxicity & Teratology Genotoxicity Epidemiology Human Study

Abstract

1) The low incidence of dental caries observed in mongoloid patients led to an investigation of the role of fluorine in this condition.

2) A statistical study of the geographical distribution of mongolism in Wisconsin, Illinois, Idaho, North and South Dakota (U.S.A.) shows a parallelism between the prevalence of this condition and the amount of fluoride in the water supply.

3) A new hypothesis on the pathogenesis of mongolism is proposed: the blockage of an enzymatic system by an inhibitor, such as fluorine, at an early stage of the fetal development.