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Effect of inhaled anesthetic gases on immune status alterations in health care workers.
Conclusions From the data of this study and the findings of other earlier studies, we can conclude that operating room personnel exposures to WAG are associated with changes in blood levels of IgG and IgM, total lymphocytes, CD4+ and CD8+ subtypes, and accordingly, in CD4:CD8 ratios. It is quite possible these changes would likely be […]
Neonatal exposure to sevoflurane induces abnormal social behaviors and deficits in fear conditioning in mice
References 1. Bayer SA, Altman J, Russo RJ, Zhang X: Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat. Neurotoxicology 1993; 14:83–144. 2. Rice D, Barone S Jr: Critical periods of vulnerability for the developing nervous system: Evidence from humans and animal models. Environ Health Perspect 2000; 108:511–33. 3. […]
Effect of dexmedetomidine on sevoflurane-induced neurodegeneration in neonatal rats.
References Lin E.P., Lee J.R., Lee C.S., Deng M., Loepke A.W. Do anesthetics harm the developing human brain? An integrative analysis of animal and human studies. Neurotoxicol Teratol. 2017; 60: 117-128. PubMed Jevtovic-Todorovic V., Olney J.W. PRO: anesthesia-induced developmental neuroapoptosis: status of the evidence. Anesth Analg. 2008; 106: 1659-1663. PubMed Loepke A.W. McGowan Jr., F.X. […]
Trace anesthetic effects on perceptual, cognitive, and motor skills.
References 1. Linde HV, Bruce DL: Occupational exposure of anesthetists to halothane. nitrous oxide and radiation. Anesthesiology 30:363-368, 1969. 2. Corbett TH: Retention of anesthetic agents following occupational exposure. Anestl, Analg (Cleve) 52:614-Gli, 1973. 3. Salvini M, Binaschi S, Riva M: Evaluation of the psychophysiological functions in humans exposed to trichloroethylene. Br J Ind Med […]
Psychological studies of human performance as affected by traces of enflurane and nitrous oxide.
Discussion The principal findings of this study were that enflurane affected performance on these tests in a manner qualitatively similar to, though quantitatively different from, halothane. Since the minimum alveolar concentration (MAC), an index of anesthetic potency, is about twice as high for enflurane as for halothane, comparison of the same trace amounts of each […]
The Abortive Lives of Modern Inhalation Anesthetics.
READERS of this periodical were probably intrigued when, in 1971, almost an entire issue was devoted to studies in volunteers of a new anesthetic, isoflurane (Forane), a novel and useful editorial departure. Since then, a series of reports in the Journal has cast further light on some of the more arcane properties of this heavily […]
Fate of fluorinated metabolites of inhalation anesthetics in man.
Neurotoxicity in operating room personnel working with gaseous and nongaseous anesthesia.
Excerpt Introduction According to experimental and field studies, exposure to more than 500 ppm of nitrous oxide(N 2O) and more than 15 ppm of haJothane and enflurane can cause performance impairment in neurobehavioral exammations (Bruce and Bach 1975, 1976; Smith and Shirley 1978; Allison et al. 1979; Edling 1980; Mahoney et al. 1988. Control of […]
Fluoride concentrations in urine of delivery ward personnel following exposure to low concentrations of methoxyflurane.
Serum fluoride levels following commencement of methoxyflurane for patient analgesia in an ambulance service.
Editor—Methoxyflurane, once a frequently used anaesthetic agent,1 is re-emerging as an inhalation analgesic. In modern practice, it is given in doses of up to 6 mL via a proprietary patient-controlled self-delivery device2 with an activated carbon filter designed to adsorb some methoxyflurane vapour from the patient’s exhaled breath.3 Methoxyflurane is an organic vapour, identified as […]