Tag: Autophagy
Showing 10 of 30:
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Molecular basis of fluoride toxicities: Beyond benefits and implications in human disorders.
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Impaired V-ATPase leads to increased lysosomal pH, results in disrupted lysosomal degradation and autophagic flux blockage, contributes to fluoride-induced developmental neurotoxicity.
1. Introduction Fluoride is widespread and unevenly distributed in the environment, and it can be rapidly absorbed into the body via water, food, and air (Johnston and Strobel, 2020). Fluoride consumption at the prescribed level is essential for human health, whereas excessive fluoride exposure is harmful to health. Groundwater, minerals, soil, household chemical products such […]
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Neuromodulatory effects of hesperidin against sodium fluoride-induced neurotoxicity in rats: Involvement of neuroinflammation, endoplasmic reticulum stress, apoptosis and autophagy.
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Challenges of fluoride pollution in environment: Mechanisms and pathological significance of toxicity – A review.
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Fluoride-Induced Sperm Damage and HuR-Mediated Excessive Apoptosis and Autophagy in Spermatocytes.
Data Availability The datasets generated during and/or analyzed during the current study are not publicly available due to our research continues, such as exploring the mechanism of up regulation of HuR caused by fluorine. Hence, our original data will not be public temporarily. [REASON(S) WHY DATA ARE NOT PUBLIC] but are available from the corresponding author on […]
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Deregulation of autophagy is involved in nephrotoxicity of arsenite and fluoride exposure during gestation to puberty in rat offspring.
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Biphasic Functions of Sodium Fluoride (NaF) in Soft and in Hard Periodontal Tissues.
1. Introduction Fluoride is well known for its use in the treatment of dental caries, either systemically or topically [1]. Fluoride intake (such as in drinking water, fluoridated toothpaste, or fluoride supplements) is the cornerstone to preventing dental caries in adults and children. Fluoride prevents dental caries by slowing down the demineralization of enamel, which […]
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Weakened interaction of ATG14 and the SNARE complex blocks autophagosome-lysosome fusion contributes to fluoride-induced developmental neurotoxicity.
Highlights NaF induced autophagosome-lysosome fusion blockage. NaF weakened the interaction of ATG14 and SNARE complex. ATG14 regulates the SNARE complex in NaF-induced developmental neurotoxicity. ATG14 upregulation restored autophagosome-lysosome fusion and autophagic flux. ATG14 upregulation protects against developmental fluoride neurotoxicity. Fluoride is capable of inducing developmental neurotoxicity, but the mechanisms involved remain unclear. We aimed to […]
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Impacts of Fluoride Neurotoxicity and Mitochondrial Dysfunction on Cognition and Mental Health: A Literature Review.
Abstract This review focuses on the synthesis of current experimental and observational data regarding the effect of fluoride exposure on childhood mental health and the role of mitochondrial function as a mechanism of action. We aggregated data on the relationships between fluoride neurotoxicity, mitochondrial function, and cognitive and mental health using PubMed. Current animal and […]
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The potential risks of chronic fluoride exposure on nephrotoxic via altering glucolipid metabolism and activating autophagy and apoptosis in ducks.