Tag: Autophagy

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Impaired V-ATPase leads to increased lysosomal pH, results in disrupted lysosomal degradation and autophagic flux blockage, contributes to fluoride-induced developmental neurotoxicity.

April 18, 2022

1. Introduction Fluoride is widespread and unevenly distributed in the environment, and it can be rapidly absorbed into the body via water, food, and air (Johnston and Strobel, 2020). Fluoride consumption at the prescribed level is essential for human health, whereas excessive fluoride exposure is harmful to health. Groundwater, minerals, soil, household chemical products such […]