Tag: Benchmark dose

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NTP Research Report on Systematic Literature Review on the Effects of Fluoride on Learning and Memory in Animal Studies: Research Report 1 [Internet]

June 9, 2021

Background: Previous systematic reviews of epidemiology studies have found support for a geographical association between high levels of naturally occurring fluoride in water (>1.5 ppm) and lower IQ in children. Most of the evidence from humans is from fluoride-endemic regions having higher background levels of fluoride compared to the fluoride concentrations historically used in community […]

A Benchmark Dose Analysis for Maternal Pregnancy Urine-Fluoride and IQ in Children.

June 9, 2021

Discussion … The increased precision using the average maternal U-F concentration as an indicator of prenatal fluoride exposure results in stronger statistical evidence of fluoride-associated deficits, compared with using cross-sectional or retrospective studies. Still, the amount of fluoride that reaches the brain during early brain development is unknown, and even the maternal U-F concentration measurements […]

Critical Windows of Fluoride Neurotoxicity in Canadian Children.

May 30, 2021

Discussion We used data from a prospective pregnancy and birth cohort to compare the associations between fluoride exposures during different developmental windows and preschool aged children’s intellectual abilities. The GEE method advances our understanding of early-life fluoride neurotoxicity by formally comparing strength of associations across windows of exposure. The strongest association between fluoride and child […]

Assessment of fluoride levels during pregnancy and its association with early adverse pregnancy outcomes.

October 1, 2020

Background and Aim: There is sparse data available on human subjects regarding the affect of excessive fluoride exposures on pregnancy. The aim of this study was to examine the association between elevated urinary fluoride levels during early pregnancy and maternal anemia and adverse fetal outcome. Patients and Methods: We enrolled 600 pregnant patients with gestational […]