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Tag: Bone Cells

Showing 3 of 3:

Fluoride & Osteoclasts

May 24, 2012

It is well established that fluoride exposure can increase bone formation by increasing the proliferation of osteoblasts. Less clear is fluoride’s impact on bone resorption and the cells (osteoclasts) that resorb bone. Many have assumed that fluoride’s main effect on bone resorption and osteoclasts is an inhibitory one (i.e., less bone resorption). While evidence does […]

Fluoride & Osteocytes

May 24, 2012

The osteocyte is a type of bone cell which is increasingly believed to play an important role in repairing defects that arise in bone, thereby maintaining the bone’s structural integrity. Because osteocytes are engulfed in fluoride-rich bone mineral and help resorb the bone as part of the remodeling process, they can be exposed to high […]

Fluoride’s Effect on Osteoblasts (Bone-Forming Cells)

April 16, 2012

As noted by the National Research Council, “[p]erhaps the single clearest effect of fluoride on the skeleton is its stimulation of osteoblast proliferation.” (NRC 2006). Osteoblasts are bone-forming cells. “Stimulatory effects of fluoride on osteoblasts result in formation of osteoid, which subsequently undergoes mineralization.” (Fisher RL, et al. 1989). If the new osteoid tissue is subsequently mineralized, […]

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    • Mission Statement
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    • Our Team
  • Key Topics
    • Frequently Asked Questions
    • EPA Lawsuit
    • National Toxicology Program (NTP) Report
    • What is Water Fluoridation?
    • Health Effects of Fluoride
    • Vulnerable Populations
    • Sources of Fluoride
    • Fluoride Controversy
    • Fluoride & The Environment
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