Tag: Bone Density
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Fluoride & Osteoclasts
It is well established that fluoride exposure can increase bone formation by increasing the proliferation of osteoblasts. Less clear is fluoride’s impact on bone resorption and the cells (osteoclasts) that resorb bone. Many have assumed that fluoride’s main effect on bone resorption and osteoclasts is an inhibitory one (i.e., less bone resorption). While evidence does […]
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Fluoride in Water & Bone Density
Interest in fluoride’s affect on bone density stems back to the mid-twentieth century, when scientists first started using fluoride as a drug to build bone mass in patients with osteoporosis. From the 1960s to the 1990s, numerous clinical trials examined the effect of high daily doses of fluoride (20-34 mg/day) on bone density and fracture […]
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The Relationship Between Fluoride, Bone Density, and Bone Strength
Although fluoride has generally been found to reduce the bone density of cortical bone, it is well documented that fluoride can increase the density of trabecular bone (aka cancellous bone). Trabecular bone is the primary bone of the spine, whereas cortical bone is the primary bone of the legs and arms. While increases in bone mass are generally […]
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Fluoride’s Differential Effect on Bone Density: Trabecular vs. Cortical Bone
Based on fluoride’s ability to increase bone mass, doctors in the 1960s began using fluoride as an experimental drug in human clinical trials as a treatment for osteoporosis. The hope was that fluoride would increase the bone density of the patients and thereby help to prevent fractures. Since fluoride was found to increase, rather than decrease, fracture […]