Tag: FEX
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Fluoride Transport and Inhibition Across CLC Transporters.
Notes 1. Fluoride is isosteric with hydroxide and can compete with phosphate and carboxylate groups, thus acting as a substrate- or transition state-like inhibitor of several enzymatic reactions (Strunecka and Strunecky 2020). 2. Higher organisms can avoid fluoride’s harmful effects, thanks to the exquisite selectivity of most of their anion channels and transporters, which limits […]
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Toward a molecular understanding of fluoride stress in a model Pseudomonas strain.
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The fluoride permeation pathway and anion recognition in Fluc family fluoride channels.
Introduction Microbes are protected from the cytoplasmic accumulation of environmental fluoride ion by export of the toxic anion via fluoride channels known as Flucs [1-3]. These small, homodimeric ion channels are remarkable proteins in two regards: first, their unusual “dual topology” architecture, in which the two subunits of the homodimer are arranged antiparallel with respect […]
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Widespread genetic switches and toxicity resistance proteins for fluoride
Abstract Most riboswitches are metabolite-binding RNA structures located in bacterial messenger RNAs where they control gene expression. We have discovered a riboswitch class in many bacterial and archaeal species whose members are selectively triggered by fluoride but reject other small anions, including chloride. These fluoride riboswitches activate expression of genes that encode putative fluoride transporters, […]
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Functional and molecular characterization of fluoride exporter (FEX) from rice and its constitutive overexpression in Nicotiana benthamiana to promote fluoride tolerance
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The fluoride transporter FLUORIDE EXPORTER (FEX) is the major mechanism of tolerance to fluoride toxicity in plants.
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Impairing fluoride export of Aspergillus fumigatus mitigates its voriconazole resistance
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Genome-wide analysis of fluoride exporter genes in plants.
References Altschul SF, Gish W, Miller W (1990) Basic local alignment search tool. J MolBiol 215(3):403–410. https://doi.org/10.1016/S0022-2836(05)80360-2 CAS Article Google Scholar Armenteros JJA, Salvatore M, Emanuelsson O (2019) Detecting sequence signals in targeting peptides using deep learning. Life Sci Alliance 2:1–14. https://doi.org/10.26508/lsa.201900429 Article Google Scholar Bailey TL, Boden M, Buske FA (2009) MEME Suite: tools […]
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Engineered fluoride sensitivity enables biocontainment and selection of genetically-modified yeasts
References Hayden, E. C. Synthetic-biology firms shift focus. Nature 505, 598 (2014). ADS PubMed Article CAS PubMed Central Google Scholar Li, M. & Borodina, I. Application of synthetic biology for production of chemicals in yeast Saccharomyces cerevisiae. FEMS Yeast Res. 15, 1–12 (2015). PubMed Article CAS PubMed Central Google Scholar Collins, J. J. & Khalil, […]
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Two New Members of CsFEXs Export Fluoride Coupled Proton Gradients and Participate in Reducing the Fluoride Accumulation in Low-Fluoride Tea Cultivars