Tag: Neurotoxicity
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The effects of fluoride on neuronal function occurs via cytoskeleton damage and decreased signal transmission
In conclusion, the effects of NaF on a cell’s survival and integrity suggested that different concentrations NaF had direct toxic effects on the Neuro-2A cell line. NaF not only reduced the expression of select axonal proteins, but also prevented the secretion and delivery of the neurotransmitter glutamate.We found that expression of glutamate and its receptor, […]
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Excessive ER stress and the resulting autophagic flux dysfunction contribute to fluoride-induced neurotoxicity.
from 4. Discussion … In order to gain a better understanding of the NaF neurotoxicity and its underlying mechanisms, the NaF-treated rats and SH-SY5Y cells were used in the present study. The MWM [Morris water maze test] results showed that exposure of rats to NaF is associated with decreased learning and memory abilities. This is […]
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Neuroprotective effect of berberine against environmental heavy metals-induced neurotoxicity and Alzheimer’s-like disease in rats.
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Effects of fluoride on synapse morphology and myelin damage in mouse hippocampus
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Developmental neurotoxicity of fluoride: a quantitative risk analysis toward establishing a safe daily dose of fluoride for children
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FDA Drug Safety Communication: FDA review results in new warnings about using general anesthetics and sedation drugs in young children and pregnant women.
The FDA has issued new information about this safety issue, see the FDA Drug Safety Communication issued on 4-27-2017. [ 12-14-2016 ] The U.S. Food and Drug Administration (FDA) is warning that repeated or lengthy use of general anesthetic and sedation drugs during surgeries or procedures in children younger than 3 years or in pregnant […]
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Neurotoxicity induced by fluoride in rat cerebral cortex
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Protective effect of lovastatin on neurotoxicity of excessive fluoride in primary hippocampal neurons
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Sodium fluoride affects zebrafish behaviour and alters mRNA expressions of biomarker genes in the brain: Role of Nrf2/Keap1
Sodium fluoride (NaF), used as pesticides and for industrial purposes are deposited in the water bodies and therefore affects its biota. Zebrafish exposed to NaF in laboratory condition showed hyperactivity and frequent surfacing activity, somersaulting and vertical swimming pattern as compared to the control group. Reactive oxygen species level was elevated and glutathione level was […]
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Melatonin ameliorates fluoride induced neurotoxicity in young rats: an in vivo evidence