Tag: Neurotoxicity
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Studies of relationships between the polymorphism of COMT gene and plasma proteomic profiling and children’s intelligence in high fluoride areas
Fluoride (F) widely exists in environment with a significant increase in body burden accumulation in recent years. Internal exposure to F due to diet including food, water, fluoride-containing dental products like toothpaste and fluoride supplements, is extensively researched. Additionally, industrial pollution and coal burning have also been reported to be major sources of internal F […]
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Neurotoxicity of sodium fluoride in rats
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Subchronic neurotoxicity in rats of the structural fumigant, sulfuryl fluoride
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Use of the Rey-Osterrieth Complex Figure Test for neurotoxicity evaluation of mixtures in children.
Excerpt 4. Discussion This study provides evidence that children living in high risk areas were exposed to either F, As, Pb, DDT or PCBs and these contaminants could contribute, to some degree, to children’s low performance observed in the tests of the Rey-Osterrieth Complex Figure. The highest proportion of children (89%) with Copy performance below […]
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JNK and NADPH oxidase involved in fluoride-induced oxidative stress in BV-2 microglia cells.
Abstract Excessive fluoride may cause central nervous system (CNS) dysfunction, and oxidative stress is a recognized mode of action of fluoride toxicity. In CNS, activated microglial cells can release more reactive oxygen species (ROS), and NADPH oxidase (NOX) is the major enzyme for the production of extracellular superoxide in microglia. ROS have been characterized as […]