Showing 10 of 12:
Chronic fluoride’s impact on pancreatic islet cells in workers.
Functional state of thyroid under extended exposure to fluorides
The issue of specific effect of fluorine on the thyroid in humans remains debatable. There is no doubt, however, that cases of experimental fluorosis are characterized by specific toxicity of fluorine to the thyroid. The hypoactivity of thyroid epithelium is observed, the destructive changes in the follicular cells increasing with the increased intoxication time (1, […]
New Report Bolsters Fluoride-Cancer Link
The evidence that fluoride may cause cancer has just become substantially stronger. In the May 19th issue of the Journal of the National Cancer Institute, a 12-year follow-up study of workers in the cryolite industry confirms earlier reports of a link between occupational fluoride exposure and bladder & lung cancer.
Clinico-hygiene assessment of the combined effect on the body of vibration and fluorine.
In the X-ray examination of vibration disease patients in fluorite mines, we observed a greater frequency of deforming osteoarthroses (DOA) of the elbow joints and osteochondrosis and spondylitis of the cervical section and of the lumbar section of the spine. The terms of development of vibration disease under the conditions in the fluorite mines were significantly shorter than those in the iron ore mines.
Radiological Modifications of the Skeletal System Among Aluminum Smelter Workers
This paper reports the frequency of occurrence of bone changes caused by fluoride in a population of 358 aluminum smelter workers who had been fluoride exposed for more than 5 years. In the examination, particular attention was paid to degenerative changes of the skeleton and the frequency of spondylosis, arthrosis of the hip and elbow joints as well as changes in the form of diffuse idiopathic skeletal hyperostosis (spondylosis hypeostotica Forestier).
Skeletal Changes in Industrial and Endemic Fluorosis
Fluorotic changes in bones and joints were evaluated in 105 aluminum workers and 20 residents of an endemic fluorosis region in India.
A highly significant relationship of exposure to fluoride was established with the frequency of back and neck surgery, fractures, symptoms of musculoskeletal disease and past history of diseases of bones and joints in the absence of the typical findings of skeletal fluorosis. Monitoring exposed workers for the early manifestations of “musculoskeletal fluorosis” is recommended prior to the development of destructive and degenerative changes of the skeleton.
Fluoride & Spondylosis; Spondylitis
Among individuals with skeletal fluorosis, the fluoride-induced changes to the spine, and the accompanying symptoms, can bear a close resemblance to spondylosis and spondylitis (as well as DISH). Spondylosis is a (non-inflammatory) degenerative disease of the spine marked by bony outgrowths (spurs) which can produce nerve cord compression. Spondylitis, by contrast, is an inflammatory form of arthritis that causes inflammation in the joints between the vertebrae. Whereas spondylosis is generally asymptomatic, spondylitis generally causes significant pain and stiffness in the spine.
Fluoride & DISH (Diffuse Idiopathic Skeletal Hyperostosis)
Among individuals with skeletal fluorosis, the fluoride-induced changes to the spine, and the accompanying symptoms, can bear a close resemblance to DISH (Forestier’s Disease). Some authors report that skeletal fluorosis can so closely resemble that DISH that the only way to distinguish the two would be to conduct an invasive bone biopsy. No studies have ever been conducted to determine what role, if any, fluoride plays in the development of DISH.
Variability in Radiographic Appearance of Skeletal Fluorosis
Osteosclerosis (dense bone) is the bone change typically associated with skeletal fluorosis, particularly in the axial skeleton (spine, pelvis, and ribs). Research shows, however, that skeletal fluorosis produces a spectrum of bone changes, including osteomalacia, osteoporosis, exostoses, changes resulting from secondary hyperparathyroidism, and combinations thereof. Although the reason for this radiographic variability is not yet fully understood, it is believed to relate to the dose of fluoride consumed, the individual’s nutritional status, exposure to aluminum, genetic susceptibility, presence of kidney disease, and area of the skeleton examined.