Tag: Osteoarthritis

Showing 10 of 16:

Treatment of osteoporosis with sodium fluoride: An appraisal.

April 7, 2015

Crippling fluorosis… is characterized by dense bones, exostoses, neurologic complications due to bony overgrowth, osteoarthritis, and ligamentous calcification. … new bone formed under the stimulus of fluoride administration may exhibit various degrees of osteosclerosis, osteoporosis, osteomalacia, and architectural disorganization. Of these manifestations, only osteosclerosis increases bone strength. When fluoride is used therapeutically, therefore, it is […]

Sodium fluoride induces apoptosis through the downregulation of hypoxia-inducible factor-1a in primary cultured rat chondrocytes

March 13, 2014

Results of previous studies have shown that fluoride has a higher and special affinity for calcium in bone tissue, which could result in osteofluorosis (19,20). It has been reported that osteofluorosis may increase the severity of osteoarthritis (OA) characterized by progressive degeneration of articular cartilage (21,22). Chondrocyte apoptosis may be involved in the onset and […]

Clinical features of early stages of occupational fluorosis under the combined and joint effect of production factors

March 11, 2014

Working conditions in the mining and processing of fluorite and in cryolite and aluminum production remain poor despite the introduction of protective measures. Every year, new cases of fluorosis are diagnosed, and in a number of regions of the country this disease is one of the foremost chronic occupational intoxications. The clinical picture of occupational […]