Tag: Sevoflurane

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Neonatal exposure to sevoflurane induces abnormal social behaviors and deficits in fear conditioning in mice

March 30, 2021

References 1. Bayer SA, Altman J, Russo RJ, Zhang X: Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat. Neurotoxicology 1993; 14:83–144. 2. Rice D, Barone S Jr: Critical periods of vulnerability for the developing nervous system: Evidence from humans and animal models. Environ Health Perspect 2000; 108:511–33. 3. […]

Effect of dexmedetomidine on sevoflurane-induced neurodegeneration in neonatal rats.

March 30, 2021

References Lin E.P., Lee J.R., Lee C.S., Deng M., Loepke A.W. Do anesthetics harm the developing human brain? An integrative analysis of animal and human studies. Neurotoxicol Teratol. 2017; 60: 117-128. PubMed Jevtovic-Todorovic V., Olney J.W. PRO: anesthesia-induced developmental neuroapoptosis: status of the evidence. Anesth Analg. 2008; 106: 1659-1663. PubMed Loepke A.W. McGowan Jr., F.X. […]

The impact of sevoflurane anesthesia on postoperative renal function: a systematic review and meta-analysis of randomized-controlled trials.

August 24, 2020

References Abbvie Ltd. ULTANE® (sevoflurane) volatile liquid for inhalation. Available from URL: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020478s030lbl.pdf (accessed June 2020).  Mazze RI. Methoxyflurane revisited: tale of an anesthetic from cradle to grave. Anesthesiology 2006; 105: 843-6. CAS  PubMed  Google Scholar  Gentz BA, Malan TP Jr. Renal toxicity with sevoflurane: a storm in a teacup? Drugs 2001; 61: 2155-62. CAS  […]

The future is now—it’s time to rethink the application of the Global Warming Potential to anesthesia

August 19, 2020

All volatile anesthetic agents are fluorocarbons and variably potent greenhouse gases (GHG).1 As a chlorofluorocarbon (CFC), isoflurane also has ozone depleting potential (as does nitrous oxide [N2O]), while sevoflurane and desflurane, being hydrofluorocarbons (HFC), do not.1 The global emission of HFCs increased 128% from 1990 to 2005 and is projected by 2030 to increase a […]