CAS No. 128621-72-7
CAS No. 128639-02-1


Return to Carfentrazone-ethyl Adverse Effects

ACTIVITY: Herbicide (unclassified)

CAS Name: ?,2-dichloro-5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazol-1-yl]-4-fluorobenzenepropanoic acid

Metabolite of concern: carfentrazone-ethyl chloropropionic acid (alpha-2-dichloro-5-[4-(difluoromethyl)-4,5-

Structure for Carfentrazone-ethyl:

Adverse Effects:

Body Weight Decrease

Endocrine: Thymus

Environmental Effects:

Highly Toxic to Aquatic Plants


major metabolites are mobile to very highly mobile in soil and have potential to leach

Data for Carfentrazone-ethyl
Regulatory Information
(only comprehensive for the US)
US EPA Registered: Yes
US EPA PC Code: 128712
California Chemical Code 5130
US Tolerances: CFR 180.515
FDA LMS Code: B21
Registered use in

(includes only a limited list of countries)


Registered use in

(includes only a limited list of countries)

Australia, China, Czech Republic, Hungary, Pakistan, Philippines, Poland, South Africa, Switzerland, UK, US

US Maximum Residue Levels per
mitted in food commodities

US - Over 700 Food Commodities

UK Temporary MRL's

Applicable from: June 2001

Potato: 0.5 p pm

Other Information
Molecular Formula: C15H14Cl2 F3 N3O3
Inventing Company: FMC
Manufacturers: FMC
Entry Year: 1992 
Other Names:

FMC 116426 

Manufacture site: US:
FMC Corporation at Quality Chemicals Inc., Tyrone Industrial Park, Tyrone Pennsylvania 16686-0216.
Of special interest:
PAN Data for Carfentrazone-ethyl
PAN Data for Carfentrazone 
Material Safety Data Sheets & Labels
January 31, 2006 - The California Department of Pesticide Regulation reports a small increase in pounds of pesticides applied in 2004, but that included a dramatic rise in the use of some nature-friendly chemicals... "A dramatic increase occurred in the use of some newer, reduced-risk pesticides such as spinosad, acetamiprid, pyraclostrobin, methoxyfenozide, carfentrazone-ethyl, and boscalid," DPR analysts reported..." Western Farm Press.
April 2000 - Australia. Evaluation of the new active CARFENTRAZONE-ETHYL in the product AFFINITY 400 DF HERBICIDE. National Registration Authority for Agricultural and Veterinary Chemicals. NRA Ref. 51555. Also available at
April 10, 2003 - Review report for the active substance carfentrazone-ethyl. Carfentrazone-ethyl 7473/VI/99-Final. Finalised in the [European Commission] Standing Committee on the Food Chain and Animal Health at its meeting on 26 February 2003 in view of the inclusion of carfentrazone-ethyl in Annex I of Directive 91/414/EEC.

February 18, 2002 - European Commission decision to extend provisional authorisation granted for new active substances: carfentrazone-ethyl, cinidon-ethyl, cyhalofop-butyl, ethoxysulfuron, famoxadone, flazasulfuron, flufenacet, flumioxazine, flurtamone, fosthiazate, isoxaflutole, metalaxyl-M, prosulfuron, Pseudomonas chlororaphis, quinoxyfen, Spodoptera exigua nuclear polyhedrosis virus and sulfosulfuron
organofluorine pesticides highlighted in red.

March 7, 2001 - Phototoxic Pesticides: US EPA Memo Requesting Phototoxicity Study Protocol for Light-Dependent Peroxidizing Herbicides
September 30, 1998 - US EPA Fact Sheet
April 2000 - Food and Drug Administration Pesticide Residue Monitoring. Table 3. Pesticides detectable by methods used in 1999 regulatory monitoring.
October 2001 -Glossary of Pesticide Chemicals. A listing of pesticides subject to analysis of residues in foods and feeds by the US Food and Drug Administration.
August 2001 - IR-4: New Products/Transitional Solution List - This list contains brief descriptions of numerous new pest control materials that have been introduced over the last several years. Additionally, it contains information on some "older" crop protection chemicals that are believed to have room for new uses. This List includes: Carfentrazone-ethyl

List of US herbicide products - as of December 2003

US Federal Register

•• Note: Due to length, the following is a partial list. Click here to see full list of FR entries.

Published Date Docket Identification Number Details
June 27, 2007 EPA-HQ-OPP-2007-0193

FMC Corporation. Pesticide Petition. PP 6F7145. Proposal to establish a tolerance for residues of the herbicide carfentrazone-ethyl and the metabolite carfentrazone-ethyl, chloropropionic acid (, 2-dichloro-5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazol-1-yl]-4-fluorobenzenepropanoic acid) in or on food commodities:

Grain, cereal, group 15 (except rice grain and sorghum grain)

NOTE: Group 15 includes 100 commodities.

0.10 ppm
rice, grain 1.3 ppm
sorghum, grain 0.25 ppm
grain, cereal, stover 0.80 ppm
grain, cereal, straw 3.0 ppm
soybean, seed 0.10 ppm
barley, flour 0.80 ppm
barley, bran 0.80 ppm
millet, flour 0.80 ppm
oat, flour 0.80 ppm
ice, hulls 3.5 ppm
rye, flour 0.80 ppm
rye, bran 0.80 ppm
wheat, bran 0.80 ppm
wheat, flour 0.80 ppm
wheat, middlings 0.80 ppm
wheat, shorts 0.80 ppm
wheat, germ 0.80 ppm
aspirated grain fractions 1.8 ppm
hog, meat 0.10 ppm
hog, meat byproducts 0.10 ppm
hog, fat 0.10 ppm
poultry, meat byproducts 0.10 ppm
sugarcane 0.15 ppm.

The analytical method involves separate analyses for parenand its metabolites. The parent is analyzed by GC/electron capture detection (ECD). The metabolites are derivatized with boron trifluoride and acetic anhydride for analysis by GC/mass spectrometry detection (MSD) using selective ion monitoring.

June 28, 2006 EPA-HQ-OPP-2006-0084

Notice of Receipt of Requests to Voluntarily Cancel Certain Pesticide Registrations.

Registration No. Product Name Registrant
000279 WA-03-0009 Aim Herbicide FMC Corp. Agricultural Products
Group, 1735 Market St,
Philadelph, PA 19103.
August 3, 2005 OPP-2005-0201

Cancellation of Pesticides for Non-payment of Year 2005 Registration Maintenance Fees.

Section 24(c) Registrations canceled for non-payment of the 2005
maintenance fee are shown in the following Table 1:

Table 1.--Section 24(c) Registrations Canceled for Non-Payment of Maintenance Fee

SLN no. Product Name
000279 WI-01-0009 Aim Herbicide

•• Note: Due to length, the above is a partial list. Click here to see full list of FR entries.

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