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National
Institute for Occupational Safety and Health (NIOSH)
Methane, chlorodifluoro -
RTECS #: PA6390000
CAS #: 75-45-6
MF: CHClF2
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE | EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST | ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
mutation in microorganisms | Salmonella typhimurium | 33 pph/24 hour- continuous (+/-enzymatic activation step) | TOLED5 2,1,1978 |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE | EFFECT | REFERENCE |
inhalation rat | lowest published toxic concentration: 50,000 ppm/5 hour (56 day male) | Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands | FAATDF 1,266,1981 |
inhalation rat | lowest published toxic concentration: 5 ppm (6-15 day pregnant) | Reproductive: Specific developmental abnormalities: Eye, ear | NTIS** OTS0520838 |
inhalation rat | lowest published toxic dose: 50,000 ppm/6 hour (6-15 day pregnant) | Reproductive: Specific developmental abnormalities: Eye, ear | NTIS** OTS0545682 |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE | EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE | EFFECT | REFERENCE |
inhalation dog | lowest published lethal concentration: 70 pph | Lung, Thorax, or Respiration: Other changes | TXAPA9 2,363,1960 |
inhalation guinea pig | lowest published lethal concentration: 30 pph/2 hour | Behavioral: General anesthetic Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold | ZAARAM 21,149,1971 |
inhalation mouse | lethal concentration (50 percent kill): 1,380 gm/m3/2 hour | Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Lung, Thorax, or Respiration: Cyanosis | TLSMA6 75,241,1963 |
inhalation rat | lethal concentration (50 percent kill): 35 pph/15 minute | Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression | HUTODJ 1,239,1982 |
oral rat | lethal dose : >43,200 µg/kg | N/R | GISAAA 48(8),69,1983 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE | EFFECT | REFERENCE |
inhalation mouse | lowest published toxic concentration: 50 gm/m3/6 hour/43 week- intermittent | Brain and Coverings: Other degenerative changes Spinal Cord: Other degenerative changes Behavioral: Alteration of classical conditioning | TLSMA6 75,231,1963 |
oral rat | lowest published toxic dose: 2,457 mg/kg/26 week- intermittent | Brain and Coverings: Other degenerative changes Blood: Changes in other cell count (unspecified) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | GISAAA 48(8),69,1983 |
REVIEWS: | ||
ORGANIZATION | STANDARD | REFERENCE |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | Not classifiable as a human carcinogen | DTLVS* TLV/BEI,1999 |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | time-weighted average 1000 ppm | DTLVS* TLV/BEI,1999 |
International Agency for Research on Cancer (IARC) Cancer Review | Animal Limited Evidence | IMEMDT 41,237,1986 |
International Agency for Research on Cancer (IARC) Cancer Review | Animal Limited Evidence | IMEMDT 71,1339,1999 |
International Agency for Research on Cancer (IARC) Cancer Review | Human Inadequate Evidence | IMEMDT 41,237,1986 |
International Agency for Research on Cancer (IARC) Cancer Review | Human Inadequate Evidence | IMEMDT 71,1339,1999 |
International Agency for Research on Cancer (IARC) Cancer Review | Group 3 | IMEMDT 71,1339,1999 |
TOXICOLOGY REVIEW | | FAZMAE 18,365,1974 |
TOXICOLOGY REVIEW | | NYSJAM 74,1939,1974 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD | REFERENCE |
Occupational Exposure Limit - AUSTRALIA | time-weighted average 1000 ppm (3500 mg/m3), short term exposure limit 1250 ppm, JAN1993 | |
Occupational Exposure Limit - AUSTRIA | MAK 500 ppm (1800 mg/m3), JAN1999 | |
Occupational Exposure Limit - BELGIUM | time-weighted average 1000 ppm (3540 mg/m3), short term exposure limit 1250 ppm, JAN1993 | |
Occupational Exposure Limit - DENMARK | time-weighted average 500 ppm (1770 mg/m3), JAN1999 | |
Occupational Exposure Limit - FINLAND | time-weighted average 1000 ppm (3500 mg/m3), short term exposure limit 1250 ppm, JAN1999 | |
Occupational Exposure Limit - FRANCE | VME 1000 ppm (3500 mg/m3), JAN1999 | |
Occupational Exposure Limit - GERMANY | MAK 500 ppm (1800 mg/m3), JAN1999 | |
Occupational Exposure Limit - HUNGARY | time-weighted average 100 mg/m3, short term exposure limit 200 mg/m3, JAN1993 | |
Occupational Exposure Limit - JAPAN | Occupational Exposure Limit 1000 ppm (3500 mg/m3), JAN1999 | |
Occupational Exposure Limit - THE NETHERLANDS | MAC-TGG 1000 ppm (3600 mg/m3), JAN1999 | |
Occupational Exposure Limit - NORWAY | time-weighted average 500 ppm (1750 mg/m3), JAN1999 | |
Occupational Exposure Limit - RUSSIA | time-weighted average 1000 ppm, short term exposure limit 3000 mg/m3, JAN1993 | |
Occupational Exposure Limit - SWEDEN | NGV 500 ppm (1800 mg/m3), KTV 750 ppm (2500 mg/m3), JAN1999 | |
Occupational Exposure Limit - SWITZERLAND | MAK- week 500 ppm (1800 mg/m3), JAN1999 | |
Occupational Exposure Limit - UNITED KINGDOM | LTEL 1000 ppm (3500 mg/m3), short term exposure limit 1250 ppm, JAN1993 | |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA | American Conference of Governmental Industrial Hygienists
(ACGIH) Threshold Limit Value; time-weighted average 1000 ppm | |
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM | American Conference of Governmental Industrial Hygienists
(ACGIH) Threshold Limit Value time-weighted average 1000 ppm |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY | REFERENCE |
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLORODIFLUOROMETHANE-air | time-weighted average 1000 ppm; short term exposure limit 1250 ppm | NIOSH* DHHS #92-100,1992 |
National Occupational Hazard Survey 1974 | National Occupational Hazard Survey 1974: Hazard Code:
80048; Number of Industries 76; Total Number of Facilities 7,420; Number of Occupations 44; Total Number of Employees Exposed 56,234 | |
National Occupational Exposure Survey 1983 | National Occupational Exposure Survey 1983: Hazard Code:
80048; Number of Industries 78; Total Number of Facilities 12,513; Number of Occupations 57; Total Number of Employees Exposed 157,080; Total Number of Female Employees Exposed 12,185 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION | REFERENCE |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9099;8EHQ-0892-9107 | |
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9108;8EHQ-0892-9117 | |
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9118 | |
On EPA IRIS database | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, OCTOBER 2000 | |
NIOSH Analytical Method, 1994: Chlorodifluoromethane, 1018 |