Return to
Adverse Effects
Abstracts
ACTIVITY: Wood
Preservative, Antifoulant, Fungicide, Acaricide
CAS Name:
1,1-dichloro-N-[(dimethylamino)sulfonyl]-1-fluoro-N-phenylmethanesulfenamide
Structure:
Adverse
Effects:
Blood
Bone
- Cranial osteosclerosis
Brain
Carginogenic
Endocrine: Ovary; Vitellogenesis
Endocrine: Pituitary
Endocrine: Suspected Disruptor
Endocrine: Testicular
Endocrine: Thyroid
Genotoxic - Potent Cytoxicant
Kidney
Liver
|
Contamination:
2001 - Denmark:
Wood preservative sold
in Denmark under the retail product name "Rentolin"
with no warning against indoor uses. Around 200 people used
Rentolin indoors and suffered serious injury.
Many houses are now uninhabitable, and several people suffer
from chronic diseases. |
Environmental
Effects:
Although
no marine data were submitted, dichlofluanid was shown to
be highly toxic to aquatic organisms.
The
most commonly used biocides in antifouling paints are: Irgarol
1051, diuron, Sea-nine 211, dichlofluanid,
chlorothalonil, zinc pyrithione, TCMS
(2,3,3,6-tetrachloro-4-methylsulfonyl) pyridine, TCMTB [2-(thiocyanomethylthio)
benzothiazole], and zineb. Since
1993, several studies have demonstrated the presence of these
biocides in European coastal environment as a result of their
increased use. More recently, the presence of these biocides
was also revealed in waters from Japan, United States, Singapore,
Australia and Bermuda. |
Regulatory
Information
(only comprehensive for the US) |
US
EPA Registered: |
No |
US
EPA PC Code: |
128844 |
FDA
LMS Code: |
588 |
Registered
use in
(includes only a limited list
of countries)
|
Australia,
China, Denmark, Germany, Hungry, Japan, New Zealand, Portugal,
South Africa, UK |
European
Commission: |
Not
allowed to be used as an active ingredient after July 25, 2003. |
Japan's
Maximum Residue Levels (MRLs) |
Partial
List: Apricot
• Apple • Banana • Barley • Beans •
Blackberry • Blueberry • Brussels sprouts •
Cabbage •
Carrot • Cauliflower • Cherry• Cranberry •
Cucumber (including Gherkin) • Eggplant • Garlic
• Ginger • Grape • Grapefruit • Hop
• Horseradish • Japanese pear • Japanese persimon
• Japanese plum (including Prunes) • KOMATSUNA •
Lettuce (Cos lettuce, Leaf lettuce) • Kidney beans (with
pods, immature) • Lemon • Lime • Nectarine
• Onion • Orange (including Navel) • Other
berries • Other cereal grains • Other Citrus fruits
• Other Fruits • Other Vegetables • Parsnip
• Peach • Pear • Peas • Peas (with pods,
immature) • Pimento (Sweet pepper) • Potato •
Raspberry • Rye • Salsify • Spinach •
Strawberry • Tea • Tomato • Watermelon •
Wheat |
Other
Information |
Molecular
Formula: |
C9H11Cl2
F N2O2S2 |
Inventing Company: |
Bayer
|
Entry Year: |
1965 |
Other
Names: |
Bay,
BAY 47531,
Dichlofluanide (France),
Elvaron, Eurparen,
Euparene, Flourofolpet,
Kue, 13032c, Preventol,
Rentolin |
Manufacture
site: |
GERMANY:
Bayer, Dormagen-Bayerwerk |
Of special interest: |
PAN
Data |
June
2005 - CHINA: Asparagus production is expected to remain relatively
high in China again this year, with the result the country will
remain an intense competitor on world processed asparagus markets.
This year;s harvest the potential to reach 400,000 metric tons
(), reports the U.S. agricultural attache for the country, with
the country exporting around $100 million worth of processed
and fresh asparagus ... An independent residue analysis laboratory
in China's vegetable export hub of Qingdao reports a range of
chemical residues are often found on agricultural products in
China that would not normally be associated with controlling
pests or disease for the commodity of concern. The lab reports
its tests on white and green asparagus did not find levels exceeding
allowable levels and that levels were less than one part per
million for tests of Atrazine, Biphenyls, Carbendazim, Dichlofluanid,
Diphenylamine, Myclobutanil, and p,p'-DDE.
Ref: China Expects 400,000 MT Asparagus Crop. Fresh
Plaza. |
Denmark:
Wood
preservative ruined 200 homes. Issue
17, Chemical Awareness (2001) |
January
2003 - Evaluation
on: Booster biocides in antifouling products. Full review of
Dichlofluanid. No. 206. Evaluation
of Fully Approved or Provisionally Approved Products.
Prepared by : The Health and
Safety Executive Biocides & Pesticides Assessment Unit Magdalen
House Stanley Precinct Bootle Merseyside L20 3QZ Available from:
Department for Environment, Food and Rural Affairs, Pesticides
Safety Directorate, Mallard House, Kings Pool, 3 Peasholme Green,
York YO1 7PX, UK. Also available at: http://www.pesticides.gov.uk/citizen/Evaluations/206_dichlofluanid.pdf |
ASSESSMENT
OF ANTIFOULING AGENTS IN COASTAL ENVIRONMENTS (ACE)
MAS3-CT98-0178 Management Report (February 2000 -July 2000)
James W Readman (Plymouth Marine Laboratory, UK.) Also available
at: http://www.pml.ac.uk/ace/sec/Feb00-Julyfinal.doc. |
ABSTRACTS |
November
26, 2002 - European
Commission: Dichlofluanid is one
of 320 pesticides to
be withdrawn in July 2003. "Some
320 substances used in plant protection products (PPPs) Ð including
insecticides, fungicides and herbicides Ð are to be withdrawn
from the market by 25 July 2003 as part of the European CommissionÕs
new approach to the evaluation of active substances in plant
protection products. This aims to improve safeguards to ensure
that all such products in use are safe for the environment and
human health. Users, wholesalers and retailers of plant protection
products will need to be aware of whether the products they
use or sell are likely to be withdrawn, so as to prevent them
being left with stocks of unusable material. Those concerned
should contact their national authority to check the authorisation
status for any particular product. The Regulation (n¡ 2076/2002
of 20 November 2002), with the list of the 320 substances, has
now been published in the Offical Journal...." Ref: MIDDAY
EXPRESS. News from the Press and Communication Service's midday
briefing. |
Citation
of hormonal activity
for Dichlofluanid in the report: BIOCIDES
(II). Refined aquatic environmental
risk assessment of 28 priority biocides. RIVM report 601506005.
B.J.W.G. Mensink. November 2000. RIVM = Rijksinstituut voor
Volksgezondheid en Milieu. National Institute of Public Health
and the Environment. http://www.rivm.nl/bibliotheek/rapporten/601506005.pdf
|
1998
- In this report Dichlofluanide was identified as:
"Very high toxicity to aquatic organisms" and
"Sensitising." The
report, entitled Examples
of substances requiring particular attention, was
issued by the Swedish National Chemicals Inspectorate in collaboration
with the Swedish Environmental Protection Agency and the Swedish
National Board of Occupational Safety and Health. NATIONAL CHEMICALS
INSPECTORATE. Order No 510 622. Second, revised edition, 1998.
See list of the specific Fluorine
and organofluorine pesticides cited in the report. |
Food
and Drug Administration Pesticide Residue Monitoring. April
2000. Table 3. Pesticides detectable
by methods used in 1999 regulatory monitoring. |
EEC
Maximum Residue Levels (MRLs). Pages
261-265. March 12, 2001 |
|