Fluazifop-butyl
CAS No. 69806-50-4
 
 

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Adverse Effects
Abstracts

ACTIVITY: Herbicide (Aryloxyphenoxy propionic acid)

See also Fluazifop-p-butyl - Fluazifop - Fluazifop-P

Systematic Names:
• Butyl 2-(4-((5-(trifluoromethyl)-2-pyridyl)oxy)phenoxy)propionate
• Propanoic acid, 2-(4-((5-(trifluoromethyl)-2-pyridinyl)oxy)phenoxy)-, butyl ester

Structure:

Adverse Effects:

Blood
Body Weight Decrease

Bone
Brain
Cholesterol
Endocrine:
Adrenal
Endocrine: Ovary
Endocrine: Pituitary
Endocrine: Suspected Endocrine Disruptor

Endocrine: Testicular
Endocrine: Thymus
Endocrine: Uterus
Eye
Fetotoxic
Gastrointestinal Tract
Kidney
Liver
Mesenteric Lymph Nodes
Spleen

Teratogenic

Environmental Effects:

Potential for bioconcentration in aquatic organisms is very high

Highly toxic to Zooplankton

Regulatory Information
(only comprehensive for the US)
US EPA Registered: Yes 
US EPA PC Code: 122805 
California Chemical Code 2186  
US Tolerances:

CFR 180.411

On May 24, 2000
CFR 185.3250
CFR 186.3250
 
were consolidated into 180.411(a)(1)

FDA LMS Code: 292
US EPA Permit Date
and Registrant:
1983, ICI 
European Commission: Not allowed to be used as an active ingredient after July 25, 2003. 
Registered use in
(includes only a limited list of countries)

Canada, Hungary, Japan, Philippines, Tanzania, US

Canada:
Flax, Mustard, Solin, Soybeans, Strawberry

Japan's Pesticide Standard Limits Partial list: All berries, Apricot, Asparagus, Avocado, Banana, Beans (dry), Broccoli, Brussel Sprouts, Cabbage, Carrot, Cauliflower, Celery, Cherry, Coffee beans, Cucumber, Endive, Garlic, Grape, Hop, Kale, Kiwifruit, Lemon, Lettuce, Mango, Nectarine, Onion, Orange, Papaya, Peach, Peanuts (dry), Pear, Pecan, Pineapple, Plum, Potato, Soybeans (dry), Strawberry, Sugar beet, Taro, Watercress, Yam  
US Maximum Residue Levels permitted in food commodities
US: including:
Asparagus, Carrots, Coffee beans, Cotton seed / oil, Eggs, Endive, Stone fruits, Cattle, Goats, Hogs, Horse, Milk, Macadamia nuts, Onions (dry bulb), Pecans, Peppers (tabasco), Poultry, Rhubarb, Sheep, Soybeans, Spinach, Sweet potatoes
 
Other Information
Molecular Formula: C19-H20-F3-N-O4  
Entry Year: 1980
Inventing Company: ISK Biosciences 
Manufacturers: ISK Biosciences
Syngenta
 
Other Names: Tornado
Onecide,
Fusilade 4E
Fusilade 2000
Fusilade Five
Fusilade Super
SL-236
IH-773B
TF-1169
ICI-A0009
PP 009
 
Of special interest:
PAN BAD ACTOR (Developmental Toxin) 
December 1, 2004 - Regulations Amending the Food and Drug Regulations (1378 — Fluazifop-butyl). Canada Gazette Part II. Vol. 138, No. 24, pages 1782 - 1785.
http://canadagazette.gc.ca/partII/2004/20041201/pdf/g2-13824.pdf
US Pesticide Use Map - 1992-1995
TOXNET profile from Hazardous Substances Data Bank 
Fluazifop-butyl. California EPA Details on Grass-B-Gon Grass Killer (cancelled) and GRASS-B-GON GRASS KILLER FORMULA II (active) 
Fluazifop-butyl: Identified by the State of California as "Known to Cause Developmental Toxicity " - Prop 65 
October 2001 - Fluazifop-butyl and Fluazifop-p-butyl. Glossary of Pesticide Chemicals. A listing of pesticides subject to analysis of residues in foods and feeds by the US Food and Drug Administration.
PAN Data for Fluazifop
PAN Data for Fluazifop-P-butyl and Fluazifop-P
April 2000 - Fluazifop-butyl. - Food and Drug Administration Pesticide Residue Monitoring. - Table 3. Pesticides detectable by methods used in 1999 regulatory monitoring. 
Abstracts 


June 14, 2001 - Implementation of the Community Strategy for Endocrine Disruptors - a range of substances suspected of interfering with the hormone systems of humans and wildlife. Communication from the Commission to the Council and the European Parliament. Commission of the European Communities, Brussels COM (2001) 262 final. (More information available at: http://europa.eu.int/comm/environment/docum/01262_en.htm )

This document presents a "priority list of substances for further evaluation of their role in endocrine disruption. During 2000, a candidate list of 553 man-made substances and 9 synthetic/natural hormones has been identified."

Organofluorine pesticides in this list include:

Substances included on the Endocrine Disruptor Liist CAS No. Substances included on the Endocrine Disruptor Liist CAS No.
Bifenthrin 82657-04-3 Flutriafol 76674-21-0
Cyhalothrin (@Karate) 91465-08-6 Fluvalinate 69409-94-5
Diflubenzuron 35367-38-5 Prodiamine 29091-21-2
Epoxiconazole - Stannane, tributylfluoro [Tributyltin fluoride] 1983-10-4
Fipronil - Thiazopyr -
Fluazifop-butyl 69806-50-4 Trifluralin -

2000 - "P" is for Poison. Update on Pesticide Use in California Schools, by TM Olle. A report by Californians for Pesticide Reform. Fluorinated pesticides cited:
Active Ingredient Product Name   Active Ingredient Product Name
Benefin
(also known as
Benfluralin)
Team,
XL 2G
  Hydramethylnon MaxForce Ant Killer Granular Bait,
MaxForce Roach Gel,
Siege
Bifenthrin Talstar Lawn & Tree   Lambda-cyhalothrin Demand CS
Bromethalin Vengence   Sulfuryl fluoride Vikane
Cyfluthrin Intruder HPX,
Tempo 20 WP
  Trifluralin Team,
Turflan
Fipronil MaxForce Ant Station,
MaxForce Roach Station,
MaxForce FC
  Unknown Fluorgard
Fluazifop-butyl Fusilade,
Fusilade II,
Ornamec
  -

US Federal Register

Note: (1) Tolerances are established for residues of the herbicide fluazifop-butyl ()-2-[4-[5-(trifluoromethyl)-2- pyridinyl]oxy]phenoxy propanoic acid [fluazifop-p-butyl], both free and conjugated and of ()-2-[4-[5-(trifluoromethyl)-2- pyridinyl]oxy]phenoxy propanoate (fluazifop-butyl), all expressed as fluazifop, in or on the following food commodities:

Published Date Docket Identification Number Details
July 30, 2003 OPP-2002-0327 US EPA's Pesticide Reregistration Performance Measures and Goals.
Candidate for Tolerance Reassessment Progress and Interim Risk Management Decision (TRED) in Fiscal Year 2004
  which runs from October 1, 2003, through September 30, 2004.
Dec 17, 1997 OPP-300503A Fluazifop-butyl. Tolerances established for residues in or on Soybean meal at 2 ppm. - FINAL RULE. Tolerances are established for residues of Fluazifop-butyl, all expressed as fluazifop
August 4, 1997 OPP-300523 Pesticides Subject to Tolerance Reassessment.
March 6, 1996 NA Fluazifop-P-butyl (Zeneca). Request to Voluntarily Cancel Fusilade 2000 herbicide. Product Number: MN-93-0002
Nov 17, 1995 NA Fluazifop-P-butyl (Zeneca). Request to Voluntarily Cancel 2 Fusilade 2000 herbicides: Product Numbers: OR-88-0016 and OR-90-0018
Nov 8, 1995 NA Fluazifop-butyl (Solaris/Monsanto). Request to voluntarily cancel GRASS-B-GON GRASS KILLER.
Jan 12, 1994 OPPTS-400082 EPA's proposal to add 41 fluorine and organofluorine chemicals to the Toxics Release Inventory (TRI). See excerpt in box above. Also available at http://www.epa.gov/tri/frnotices/59fr1788.htm
1983 NA TOLERANCES AND EXEMPTIONS FROM TOLERANCE FOR PESTICIDE CHEMICALS IN OR ON RAW AGRICULTURAL COMMODITIES
FED REGIST 48:19026-19027,1983. (Ref. Toxline at Toxnet)
 
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