Pesticide Emergency Exemptions:

• Michigan. EPA authorized the use of sulfentrazone on strawberries to control broadleaf weeds; June 25, 2005 to December 15, 2005. Contact: (Andrew Ertman).

Cancellation of Pesticides for Non-payment of Year 2005 Registration Maintenance Fees.

Extension of Tolerances for Emergency Exemptions. FINAL RULE. EPA has authorized under FIFRA section 18 the use of sulfentrazone on lima beans and cowpeas for control of hophornbeam copperleaf in Tennessee. This regulation extends a time-limited tolerance for combined residues of the herbicide sulfentrazone and the metabolites 3-hydroxymethyl sulfentrazone and 3-desmethyl sulfentrazone in or on succulent bean seed without pod at 0.1 ppm for an additional 3-year period. This tolerance will expire and is revoked on December 31, 2007. A time-limited tolerance was originally published in the Federal Register of September 21, 1999 (64 FR 51060) (FRL-6097-8).

Note: This FR of Sept 21, 1999, titled "Sulfentrazone; Pesticide Tolerances for Emergency Exemptions" stated:
-- Developmental toxicity studies - Rats: In EPA's oral developmental study in rats, the maternal (systemic) NOAEL was 25 mg/ kg/day, based on increased relative spleen weights and splenic extramedullary hematopoiesis at the LOAEL of 50 mg/kg/day. The developmental (fetal) NOAEL was 10 mg/kg/day, based on decreased mean fetal weight and retardation in skeletal development as evidenced by increased numbers of litters with any variation and by decreased numbers of caudal vertebral and metacarpal ossification sites at the LOEL of 25 mg/kg/day.
-- The developmental (fetal) NOAEL was 100 mg/kg/day, based on decreased fetal weight and increased fetal variations (hypoplastic or wavy ribs, incompletely ossified lumbar vertebral arches, incompletely ossified ischia or pubes, and reduced numbers of thoracic vertebral and rib ossification sites) at the LOAEL of 250 mg/kg/day.
-- Reproductive toxicity study -- Rats. In the 2-generation reproductive toxicity study in rats- The reproductive NOAEL was 14/16 mg/kg/day, based on: (a) Increased duration of gestation in both F1 and F2 dams; (b) decreased fertility in F1 generation (males); and/or (c) atrophy of the germinal epithelium of the testes, oligospermia and intratubular degeneration of the seminal product in the epididymis at the LOAEL of 33/40 mg/kg/day.
-- Chronic risk. RfD = 0.14 mg/kg/day. For chronic dietary risk assessment the Agency recommended use of the NOAEL of 14 mg/kg/day with an uncertainty factor of 100, based on:

(a) Decreased maternal body weight and/or body weight gain during gestation in both P and F1 generations;
(b) reduced premating body weight gains in the second generation (F1 adults);
(c) increased duration of gestation in both F1 and F2 dams;
(d) reduced prenatal viability (fetal and litter);
(e) reduced litter size;
(f) increased number of stillborn pups;
(g) reduced pup and litter postnatal survival;
(h) decreased pup body weights throughout lactation;
(i) decreased fertility in F1 generation males; and
(j) atrophy of the germinal epithelium of the testes, oligospermia and intratubular degeneration of the seminal product in the epididymis at the L

Five Pesticide Emergency Exemptions.
• Michigan - EPA authorized the use of sulfentrazone on strawberries to control broadleaf weeds; June 25, 2004 to December 15, 2004. Contact: (Andrew Ertman)
• Montana - On May 10, 2004, for the use of sulfentrazone on flax to control kochia. This program ended on June 30, 2004. Contact: (Andrew Ertman)
• Ohio - EPA authorized the use of sulfentrazone on strawberries to control groundsel; June 3, 2004 to December 15, 2004. Contact: (Andrew Ertman)
• Tennessee
--- Crisis: On May 14, 2004, for the use of sulfentrazone on cowpeas to control Hophornbeam Copperleaf. This program is expected to end on September 30, 2004. Contact: (Andrew Ertman)
--- Specific: EPA authorized the use of sulfentrazone on cowpeas to control Hophornbeam Copperleaf; May 14, 2004 to September 30, 2004. Contact: (Andrew Ertman)

Pesticide Emergency Exemptions.
North Dakota - EPA authorized the use of sulfentrazone on flax to control kochia; April 1, 2004 to June 30, 2004.
Oregon - EPA authorized the use of sulfentrazone on strawberries to control broadleaf weeds; March 26, 2004 to February 28, 2005.
South Dakota - EPA authorized the use of sulfentrazone on flax to control ALS-resistant kochia; May 16, 2004 to June 30, 2004.
Washington - EPA authorized the use of sulfentrazone on strawberries to control broadleaf weeds; March 17, 2004 to February 28, 2005.
Wisconsin - EPA authorized the use of sulfentrazone on strawberries to control broadleaf weeds; June 20, 2004 to December 15, 2004.

Sept 24, 2003

OPP-2003-0270

Emergency Exemptions for pesticide use.

Colorado Department of Agriculture. EPA authorized the use of sulfentrazone on potatoes to control ALS- inhibitor and triazine-resistant kochia; March 2, 2003 to June 15, 2003.

Colorado Department of Agriculture. EPA authorized the use of sulfentrazone on sunflowers to control broadleaf weeds; April 1, 2003 to July 1, 2003.

Kansas Department of Agriculture. EPA authorized the use of sulfentrazone on sunflowers to control kochia; April 15, 2003 to July 1, 2003.

Minnesota Department of Agriculture. EPA authorized the use of sulfentrazone on horseradish to control broadleaf weeds; April 1, 2003 to July 1, 2003.

Minnesota Department of Agriculture. EPA authorized the use of sulfentrazone on sunflowers to control kochia; April 15, 2003 to June 30, 2003.

Missouri Department of Agriculture EPA authorized the use of sulfentrazone on sunflowers to control broadleaf weeds; April 1, 2003 to July 31, 2003.

Montana Department of Agriculture. Specific: EPA authorized the use of sulfentrazone on chick peas to control wild buckwheat; March 13, 2003 to June 30, 2003.

Montana Department of Agriculture. EPA authorized the use of sulfentrazone on dry peas to control wild buckwheat; March 13, 2003 to June 30, 2003.

Montana Department of Agriculture. EPA authorized the use of sulfentrazone on sunflowers to control kochia; March 15, 2003 to June 30, 2003.

Nebraska Department of Agriculture EPA authorized the use of sulfentrazone on chickpeas to control broadleaf weeds; March 27, 2003 to July 1, 2003.

Nebraska Department of Agriculture. EPA authorized the use of sulfentrazone on sunflowers to control broadleaf weeds; April 1, 2003 to July 1, 2003.

Nebraska Department of Agriculture. EPA authorized the use of sulfentrazone on potatoes to control ALS- inhibitor and triazine-resistant Palmer amaranth, redroot pigweed, and common waterhemp; April 10, 2003 to June 30, 2003.

North Dakota Department of Agriculture. EPA authorized the use of sulfentrazone on flax to control kochia and ALS-resistant kochia; April 1, 2003 to June 30, 2003.

North Dakota Department of Agriculture. EPA authorized the use of sulfentrazone on chick peas to control wild buckwheat; April 1, 2003 to June 30, 2003.

North Dakota Department of Agriculture. EPA authorized the use of sulfentrazone on field peas to control wild buckwheat; April 1, 2003 to June 30, 2003.

North Dakota Department of Agriculture. EPA authorized the use of sulfentrazone on sunflowers to control kochia; April 15, 2003 to June 30, 2003.

Oklahoma Department of Agriculture. EPA authorized the use of sulfentrazone on sunflowers to control broadleaf weeds; April 15, 2003 to July 15, 2003.

South Dakota Department of Agriculture. EPA authorized the use of sulfentrazone on chick peas to control kochia; April 1, 2003 to June 30, 2003.

South Dakota Department of Agriculture. EPA authorized the use of sulfentrazone on dry peas to control kochia; April 1, 2003 to June 30, 2003.

Texas Department of Agriculture. EPA authorized the use of sulfentrazone on sunflowers to control broadleaf weeds; March 20, 2003 to June 30, 2003.

Washington Department of Agriculture. EPA authorized the use of sulfentrazone on strawberries to control broadleaf weeds; March 15, 2003 to February 28, 2004.

Wisconsin Department of Agriculture, Trade, and Consumer Protection. EPA authorized the use of sulfentrazone on horseradish to control broadleaf weeds; April 15, 2003 to July 15, 2003.

Wisconsin Department of Agriculture, Trade, and Consumer Protection. EPA authorized the use of sulfentrazone on strawberries to control common groundsel; June 20, 2003 to December 15, 2003.

Wyoming Department of Agriculture. EPA authorized the use of sulfentrazone on sunflowers to control broadleaf weeds; April 15, 2003 to June 30, 2003.

IR-4 and FMC. Seven Pesticide Petitions:
IR-4: 0E6149 proposes the establishment of a tolerance for sunflower, seed at 0.2 ppm;
IR-4: 1E6311 proposes the establishment of tolerances for horseradish, roots at 0.2 ppm, cabbage at 0.2 ppm, peppermint, tops at 0.3 ppm, and spearmint, tops at 0.3 ppm.
IR-4: 2E6405 proposes the establishment of a tolerance for potato at 0.1 ppm.
IR-4: 2E6498 proposes the establishment of a tolerance for bean, lima, succulent at 0.15 ppm.
IR-4: 2E6500 proposes the establishment of a tolerance for asparagus at 0.15 ppm.
FMC: 0F6116 proposes the establishment of tolerances for peanut nutmeat and its processed parts at 0.2 ppm, and sugarcane and its processed parts at 0.1 ppm.
FMC: 2F6391 proposes the establishment of tolerances for corn, field, forage at 0.25 ppm, corn, field, stover at 0.35 ppm; pea and bean, dried shelled, except soybean, subgroup 6C at 0.15 ppm.
-- Genotoxicity... A mouse lymphoma forward gene mutation assay yielded negative results with equivocal results without activation.
-- Reproductive and developmental toxicity. Significant treatment-related increases in the fetal and litter incidences of incompletely ossified lumbar vertebral arches, hypoplastic or wavy ribs, and incompletely ossified or nonossified ischia or pubes occurred at the high-dose (250 mg/kg/day). An additional significant increase in the high-dose fetal incidence of variations in the sternebrae (incompletely ossified or unossified) was not judged to be treatment-related. At 250 mg/kg/day, the mean numbers of thoracic vertebral and rib ossification sites were significantly decreased, a high-dose effect of treatment with sulfentrazone consistent with the significant treatment-related hypoplasia observed in the skeletal evaluation of the ribs.
-- A developmental toxicity study in rabbits... Skeletal evaluation in fetuses revealed dose-related and treatment-related findings at the 375 mg/kg/day dose level. These included significant increases in both the fetal and litter incidences of fused caudal vertebrae (a malformation) and of partially fused nasal bones (a variation). In addition, at 375 mg/kg/day, significant treatment- related reductions in ossification site averages were observed for metacarpals and both forepaw and hindpaw phalanges.
-- A 2-generation reproduction study in the rat at dietary levels of 14, 33, or 46 mg/kg/day in males and 16, 40, or 56 mg/kg/day in females established a NOAEL for systemic and reproductive/developmental parameters of 14 mg/kg/day for males and 16 mg/kg/day for females... Systemic effects were comprised of decreased body weight gains, while reproductive/ developmental effect at the LOAEL included degeneration and/or atrophy in the testes, with epididymal sperm deficits, in the second (F1) generation males. Male fertility in the F1 generation was reduced at higher doses; litter size, pup survival, and pup body weight for both generations were also effected at higher doses.
-- Subchronic toxicity. A 90-day subchronic toxicity study was conducted in rats, with dietary intake levels of 0, 3.3, 6.7, 19.9, 65.8, 199.3, or 534.9 mg/kg/day for males and 0, 4, 7.7, 23.1, 78.1, 230.5, or 404.3 mg/kg/day for females respectively. NOAELs of 19.9 mg/ kg/day in males and 23.1 mg/kg/day in females were based on clinical anemia.
-- A 90-day subchronic feeding study was conducted in mice by dietary admix at doses of 0, 10.3, 17.8, 60.0, 108.4, or 194.4 mg/kg/day for males and 0, 13.9, 29.0, 79.8, 143.6, or 257.0 mg/kg/day for females, respectively. NOAELs of 60 mg/kg/day (males) and 79.8 mg/kg/day (females) were based on decreases in body weights and/or gains; decreased erythrocytes, hemoglobin (Hgb) and hematocrit (HCT) values; and splenic microscopic pathology.
-- In a 90-day subchronic feeding study in dogs administered by dietary admix at doses of 0, 10, 28, or 57 mg/kg/day for males and 0, 10, 28, or 73 mg/kg/day for females, a NOAEL of 28 mg/kg/day was determined for both males and females based on decreases in Hgb and HCT, elevated alkaline phosphatase levels, increased liver weights and microscopic liver as well as splenic changes.
-- Chronic toxicity. A 12-month feeding study in dogs was dosed at levels of 0.0, 24.9, or 61.2 mg/kg/day for male dogs and 0.0, 10.4, 29.6, or 61.9 [[Page 11100]] mg/kg/day for female dogs in the control through high-dose groups, respectively, with a NOAEL of 24.9 mg/kg/day for males and 29.6 mg/kg/ day for females based on hematology effects and microscopic liver changes.
-- In a 24-month chronic feeding/carcinogenicity study in rats at dietary doses of 0, 24.3, 40.0, 82.8, or 123.5 mg/kg/day for males and 20.0, 36.4, 67.0, or 124.7 mg/kg/day for females, an overall NOAEL of 40.0 mg/kg/day in males and 36.4 mg/kg/day in females was based on hematology effects and reduced body weights. There was no evidence of a carcinogenic response.

Pesticide Emergency Exemptions.

Michigan. Specific: EPA authorized the use of sulfentrazone on strawberries to control broadleaf weeds; October 21, 2002 to December 15, 2002.

Extension of Tolerances for Emergency Exemptions. EPA has authorized under FIFRA section 18 the use of sulfentrazone on horseradish for control of weeds in Wisconsin, Minnesota, and Illinois; sugarcane for control of weeds in Louisiana; and sunflowers for control of weeds in Montana, North Dakota, Minnesota, Wyoming, Texas, Nebraska, Oklahoma, Missouri, South Dakota, Kansas, and Colorado. This regulation extends a time-limited tolerance for combined residues of the herbicide sulfentrazone, N-[2,4-dichloro- 5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazol-1- yl]phenyl]methanesulfonamide, and its metabolites 3-hydroxymethyl sulfentrazone (HMS) and 3-desmethyl sulfentrazone (DMS) in or on horseradish, roots at 0.1 ppm, sugarcane at 0.05 ppm, and sunflower at 0.1 ppm for an additional 3-year period. These tolerances will expire and are revoked on December 31, 2005. A time-limited tolerance was originally published for sunflowers in the Federal Register of September 21, 1999 (64 FR 51060) (FRL-6097-8). Time-limited tolerances were originally published for horseradish and sugarcane in the Federal Register of November 9, 2000 (65 FR 67272) (FRL-6751-7).

EPA approved the use of Sulfentrazone for 5 Emergency Exemption.

-- Colorado: Crisis: On June 4, 2002, for the use of sulfentrazone on potatoes to control broadleaf weeds. This program ended on July 1, 2002.
-- Louisiana: On May 6, 2002, for the use of sulfentrazone on sugarcane to control morning glories. This program is expected to end on December 31, 2002.
-- Louisiana: Specific: EPA authorized the use of sulfentrazone on sugarcane to control morning glories; May 6, 2002 to December 31, 2002.
-- Nebraska: Crisis: On May 21, 2002, for the use of sulfentrazone on potatoes to control broadleaf weeds. This program ended on July 1, 2002.
-- Pennsylvania: Specific: EPA authorized the use of sulfentrazone on strawberries to control common groundsel; June 26, 2002 to December 15, 2002.

Emergency Exemptions for pesticide use.

Colorado Department of Agriculture - EPA authorized the use of sulfentrazone on chickpeas to control broadleaf weeds; April 24, 2002 to June 30, 2002.

Illinois Department of Agriculture - EPA authorized the use of sulfentrazone on horseradish to control broadleaf weeds; April 15, 2002 to July 15, 2002.

Minnesota Department of Agriculture - EPA authorized the use of sulfentrazone on horseradish to control broadleaf weeds; April 15, 2002 to July 15, 2002.

Montana Department of Agriculture - EPA authorized the use of sulfentrazone on chickpeas and dried peas to control kochia; April 9, 2002 to June 30, 2002.

Nebraska Department of Agriculture - EPA authorized the use of sulfentrazone on chickpeas to control broadleaf weeds; April 12, 2002 to July 1, 2002.

Nebraska Department of Agriculture - EPA authorized the use of sulfentrazone on potatoes to control broadleaf weeds; May 21, 2002 to July 1, 2002.

North Dakota Department of Agriculture - EPA authorized the use of sulfentrazone on flax to control kochia and ALS-resistant kochia; April 1, 2002 to June 30, 2002.

South Dakota Department of Agriculture - Specific: EPA authorized the use of sulfentrazone on chickpeas and dried peas to control kochia; April 9, 2002 to June 30, 2002.

Tennessee Department of Agriculture - Specific: EPA authorized the use of sulfentrazone on lima beans and cowpeas to control hophornbeam copperleaf; May 30, 2002 to September 30, 2003.

Wisconsin Department of Agriculture, Trade, and Consumer Protection - EPA authorized the use of sulfentrazone on horseradish to control broadleaf weeds; April 15, 2002 to July 15, 2002.

Wisconsin Department of Agriculture, Trade, and Consumer Protection - EPA authorized the use of sulfentrazone on strawberries to control common groundsel; June 20, 2002 to December 15, 2002.

Pesticide Emergency Exemptions. EPA authorized the use in:

Colorado: on sunflowers to control broadleaf weeds; March 16, 2001 to July 1, 2001.

Kansas: on sunflowers to control kochia; March 15, 2001 to June 15, 2001.

Louisiana: on sugarcane to control morning glory; March 14, 2001 to Dec 31, 2001.

Minnesota: on sunflowers to control kochia; March 15, 2001 to June 30, 2001.

Missouri: on sunflowers to control broadleaf weeds; March 28, 2001 to July 31, 2001.

Montana: Crisis: On April 26, 2001, for the use on chickpeas and dried peas to control wild buckwheat. This program ended on June 30, 2001.

Montana: on sunflowers to control kochia; March 15, 2001 to June 30, 2001.

Nebraska: on sunflowers to control broadleaf weeds; March 16, 2001 to July 1, 2001.

North Dakota: on chickpeas and dry peas to control wild buckwheat. This program ended on June 30, 2001.

North Dakota: on sunflowers to control kochia; March 15, 2001 to June 30, 2001.

North Dakota: on chick peas and dry peas to control wild buckwheat; April 24, 2001 to June 30, 2001.

Ohio: on strawberries to control common groundsel; June 20, 2001 to December 15, 2001.

Oklahoma: on sunflowers to control broadleaf weeds; May 3, 2001 to July 15, 2001.

South Dakota: Crisis: On April 19, 2001, for the use on chickpeas and dried peas to control kochia. This program ended on June 30, 2001.

South Dakota: on sunflowers to control kochia; March 16, 2001 to June 30, 2001.

Tennessee: on lima bean to control hophornbeam copperleaf; April 16, 2001 to September 30, 2001.

Tennessee: on cowpea to control hophornbeam copperleaf; April 16, 2001 to September 30, 2001.

Texas: on sunflowers to control broadleaf weeds; March 28, 2001 to June 30, 2001.

Wyoming: on sulflowers to control broadleaf weeds; March 30, 2001 to July 1, 2001

Pesticide Tolerances for Emergency Exemptions. - FINAL RULE.

FMC - Establishment of a Temporary Tolerance of 0.05 ppm for Soybeans.

FMC - Conditional approval of 5 Pesticide Product Registrations.
The applications were approved on February 27, 1997, for
1. Sulfentrazone Technical for manufacturing use only (EPA Registration No. 279-3149).
2. Authority 4F (formerly Sulfentrazone 4F) for preemergence and preplant incorporated weed control in soybeans (EPA Registration No. 279-3146).
3. Authority 75DF (formerly Sulfentrazone 75DF for preemergence and preplant incorporated weed control in soybeans (EPA Registration No. 279-3148)
4. Authority BL for use on soybeans in preemergency, preplant incorporated, no-till, and minimum till applications (EPA Registration No. 279-3175)
5. Authority Broadleaf for use on soybeans in preemergency, preplant incorporated, no-till, and minimum till applications (EPA Registration No. 279-3179).

FMC - Pesticide Tolerance Petition for residues in or on Soybeans.

FMC - Extension of Experimental Use Permits.

FMC - Application to register 3 pesticide products.