New
Chemicals Markedly Inhibit Cholinesterase.
Authors:
Anon
Author
Address: National Institutes of Health, Bethesda, MD.
Source:
Govt Reports Announcements & Index (GRA&I), Issue 23, 1986
Abstract:
TD3: This citation summarizes a one-page announcement of
technology available for utilization. Chemicals that markedly
inhibit the enzyme cholinesterase (ChE) in the rat brain
but relatively little in other tissues have been discovered
by Dr. Donald E. Moss and his colleagues at the University
of Texas at EL Paso (UTEP). Dr. Moss and his colleagues
found that phenylmethanesulfonyl fluoride (PMSF) and
methanesulfonyl fluoride (MSF) inhibited 90 percent of ChE
activity in the rat brain but less than 35 percent
in other tissues. The enzyme hydrolyzes acetylcholine, a
vital neurotransmitter. Acetylcholine
is markedly deficient in the brains of patients with Alzheimer
disease, due at least in part to decreased synthesis,
Dr. Moss points out. 'A therapeutic strategy, therefore,
would be to cut down ChE's destructive action so that the
little bit of neurotransmitter that is being synthesized
lasts longer,' he says. Dr. Moss points out that a big advantage
of MSF and PMSF over other drugs is their apparent l
Keywords:
Cholinesterase inhibitors
Enzyme inhibitors
Phenylmethanesulfonyl fluoride
Methanesulfonyl fluoride
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