Sulfluramid
CAS No. 4151-50-2

 
 

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Adverse Effects
Abstracts

ACTIVITY: Acaricide, Insecticide (unclassified)

CAS Name: N-ethyl-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-1-octanesulfonamide

Structure:

Adverse Effects:

Endocrine: Testicular
Fetotoxic
Kidney
Reproductive/Developmental

See also PFOA perfluorinated chemicals

Environmental Effects:

As a class, fluorinated organic compounds are resistant to microbial degradation and photolysis.

The estimated volatilization half-life from a model pond is 107 years if adsorption is considered. An estimated BCF of 500 suggests the potential for bioconcentration in aquatic organisms is high.

Violation: August 22, 2001

Largest Pesticide Penalty in New York State history - $950,000 - against S.C. Johnson for illegally distributing unsafe sulfluramid roach baits.

According to Attorney General Spitzer. "This product was marketed for home use and was labeled as child resistant when it was not."

"... According to an EPA assessment, if a child ingested the bait, he or she could suffer irreversible reproductive damage, and boys could be rendered infertile."
Ref: August 22, 2001 Press Release. Office of the New York State Attorney General Eliot Spitzer.
http://www.fluorideaction.org/pesticides/sulfluramid.largest.fine.01.htm

December 9, 2002: In a "Significant New Use Rule" - published in the Federal Register, EPA states:

All pesticide products containing sulfluramid are under a specific timeline to be phased out by 2016. The pesticide products that are registered are for use in a variety of enclosed termite, ant, and roach bait stations. These products are pre-filled and sold only in child-resistant packaging. Products containing sulfluramid have not been registered for food or crop uses.

Update: On Oct 29, 2008, EPA released a mostly usless review document on sulfluramid (see Federal Register entry below). They stated that the sale of the current 7 sulfluramid products will end on December 31, 2013.

Regulatory Information
(only comprehensive for the US)
US EPA Registered: Yes 
US EPA PC Code: 128992 
California Chemical Code 2314  
US EPA Permit Date
and Registrant:
1989, Griffin 
Registered use in
(includes only a limited list of countries)

New Zealand, US  
Other Information
Molecular Formula: C10H6 F17 NO2S  
Other Names:

Finitron
Firstline
FluorGuard
Frontline
GX-071
 

• See list at bottom of page

Manufacture site:

US

King's Laboratory, Inc
424 Blythewood Road Blythwood, South Carolina 29016
 

Of special interest:
PAN Data
Material Safety Data Sheets & Labels
March 1989 - US EPA Fact Sheet
Material Safety Data Sheet for FMC's FluorGuard Ant Bait Station Insecticide
Material Safety Data Sheet for FMC's Frontline termite bait station 
Material Safety Data Sheet for FMC's Firstline Termite Bait
Material Safety Data Sheet for Whitmire Micro-Gen Ant Bait Stations Formula 1
Specimen label for FMC's FluorGuard Ant Control Baits
Speciment label for Firstline Termite Bait Station
Overview: Hazardous Substances Data Bank 
Abstracts   
Pesticide Products - partial list 
October 1998 - Structural Pest Management pesticides. FAN's compilation of information cited on fluorine and organofluorine pesticides published in General Pest Management, Category 7A. A Guide for Commercial Applicators. Prepared by: Carolyn Randall, MSU Pesticide Education Program. Published by MSU Pesticide Education (Michigan State University). MSU manual number: E-2048.


All pesticide products containing sulfluramid are under a specific timeline to be phased out by 2016. The pesticide products that are registered are for use in a variety of enclosed termite, ant, and roach bait stations. These products are pre-filled and sold only in child-resistant packaging. Products containing sulfluramid have not been registered for food or crop uses.
[Note: see above, largest fine in NY state history against manufacturer of sulfluramid roach baits because they were not "child resistant."]

Ref: Federal Register. Vol. 67, No. 236. December 9, 2002. Perfluoroalkyl Sulfonates; Significant New Use Rule. Final Rule.
http://www.fluorideaction.org/pesticides/pfos.pfas.fr.dec.9.2002.pdf

Negotiated phase-out of sulfluramid and LPOS pesticides -- The Agency [EPA] has succeeded in negotiating a phase-out of pesticide products containing sulfluramid or LPOS (the active ingredient) with the following companies: Griffin L.L.C., FMC Corporation, Chemsico, S.C. Johnson & Son, Inc., and Whitmire Micro-Gen Research Laboratories, Inc. These chemicals are in the same chemical class as the perfluorooctyl sulfonates (PFOS related) which 3M Company announced last year it would be phasing out of its product line (May 16, 2000). The Office of Pollution Prevention and Toxics (OPPT), has been working closely with the non-pesticide applications of these chemicals to promote product stewardship and responsible environmental management with the user community. In large part driven by the long half-life of these chemicals, EPA has concerns related to reproductive effects and to ecological effects from either the purposeful use or the inadvertent exposure to the environment of these products. Sulfluramid and LPOS are formulated in bait stations for the control of ants, roaches, termites, wasps and hornets in and around homes. The registrants associated with these products are interested in product stewardship ideals and, therefore, have agreed to either immediately voluntarily cancel some of their products or agree to a time line under which these products will be phased-out. Of most interest to OPP is the fact that there will be no new sulfluramid stock produced from which to manufacture more of these products/baits. OPP views this negotiated phase-out as a win for human health and the environment. [OPMP Update 8/6/01].
Ref: Maryland Cooperative Extension Newsletter, Pesticide Notes. August 2001. Vol 20, No. 8

http://pest.umd.edu/spatc/PesticideNotes/20-8.pdf



US Federal Register
Date Published Docket Identification Number Details
Oct 29, 2008 EPA-HQ-OPP-2007-1082

Sulfluramid Registration Review Final Decision; Notice of Availability. This notice announces the availability of EPA's final registration review decision for the pesticide case sulfluramid.

Title of Review document:
Sulfluramid. Proposed Registration Review Final Decision. Registration Review Case 7411. June 2008.
Steven Bradbry, Ph.D., Director, Special Review and Reregistration Division.
[Docket No. EPA-HQ-OPP-2007-1082-0012]

PAGE 4: Sulfluramid (N-Ethylperfluorooctanesulfonamide) is a perfluorinated compound, whose major degradate is perfluoroctylsulfonate (PFOS). Sulfuramid is currently only registered for use as a termiticide in pre-filled bait stations (including perforated tubes and stakes) that are placed around building perimeters (residential, food establishments, and other institutions) to manage termites. All products containing sulfluramid must be contained in child-resistant packaging (CRP). In 2001, the Agency completed human health and ecological risk assessments for products containing sulfluramid. Because of the potential toxicity concern resulting from bioaccumulation of PFOS in animals, as well as evidence of developmental and reproductive effects in toxicity studies, EPA negotiated with the technical and end-use registrants a phase-out of products containing sulfluramid, with all registrations set to expire by December 31, 2016. Additionally, all affected registrants agreed to discontinue producing any additional sulfluramid manufacturing-use product (MUP) and the acquisition or importation of any additional sulfluramid into the U.S.

At the beginning of the registration review process for sulfluramid, which began in 2007, the technical registrant had indicated that they exhausted their supply of technical sulfluramid. After holding discussions with the end-use registrants, the Agency renegotiated the phase-out terms for all remaining product registrations to expire by December 31, 2012. End-use registrants will be permitted to sell existing stocks for one additional year after the expiration of the product registrations. Currently, there are seven remaining registered end-use products that contain sulfluramid as an active ingredient. The Agency issued the product cancellation order for the last remaining manufacturing-use product registration on May 16, 2008.

Table 1. Registered Sulfluramid Products [PAGE 7]
EPA Registration Number Company Name Product Name
279-3153
FMC Corporation
Firstline Termite Bait Station
279-3170 Firstline Termite Bait Tube Station
279-3171 Firstline Termite Bait Container Station
279-3196 Firstline GT Plus Termite Bait Station
9688-134
Chemisco,
Division of United
Industried Corporation
Chemisco Insect Bait A
9688-199 Chemisco Insect Bait SS
9688-209 Chemisco Insect Bait REP

In the sulfluramid human health assessment, available information showed that sulfluramid rapidly metablizes to PFOS. PFOS cannot be further metabolized, and is excreted extremely slowly from the body. PFOS accumulated in various organs, primarily in the liver, and recirculates enterohepatically. Although exposure to PFOS was not directly associated with toxicity effects, EPA had concerns with the persistent systemic bioavailability, which can be up to several years. Evidence of developmental and reproductive effecgts was also seen in available sulfluramid toxicity studies...

See also: Perfluoroalkyl Sulfonates; Significant New Use Rule. Final Rule. December 8, 2002. Docket No. EPA-HQ-OPP-2007-1082-004

May 16, 2008 EPA-HQ-OPP-2007-1082

Sulfluramid; Product Cancellation Order. Notice. This notice announces EPA's order for the cancellation, voluntarily requested by the registrant and accepted by the Agency, of products containing the pesticide sulfluramid. The cancellations are effective May 16, 2008.

EPA Registration Number Company Name Product Name
352-710
DuPont Crop Protection
P.O. Box 30
Newark, DE 19714-0030
EPA Company Number: 352
Finitron Brand SulfluramidTermite MUP
Oct 28, 2005 OPP-2005-0285

Notice of Receipt of Requests to Voluntarily Cancel Certain Pesticide Registrations.
Under terms of a memorandum of agreement the effective date of cancellation for these four registrations will be December 31, 2005, and the existing stocks date will be December 31, 2006. The four registrations in question are:

Registration no. Product Name Registrants Requesting Voluntary Cancellation
001812-00451 Finitron Brand Sulfluramid AB MUP Dupont Crop Protection/stine-
Haskell Research Center,
Agent For:
Griffin L.L.C
.,
PO Box 30, Newark, DE 19714-0030
001812-00348 Volcano Ant Bait Dupont Crop Protection/stine-
Haskell Research Center,
Agent For:
Griffin L.L.C
.,
PO Box 30, Newark, DE 19714-0030
000279-03154 Fluoguard Ant Control Baits FMC Corp. Agricultural Products Group,
1735 Market St,
Philadelphia, PA 19103
000499-00459 Micro-Gen Ant Reactor Whitmire Micro-Gen Research Laboratories Inc.,
3568 Tree Ct. Industrial Blvd.,
St Louis, MO 63122-6682
Dec 9, 2002 OPPT-2002-0043

Perfluoroalkyl Sulfonates; Significant New Use. FINAL RULE.
--
"All pesticide products containing sulfluramid are under a specific timeline to be phased out by 2016. The pesticide products that are registered are for use in a variety of enclosed termite, ant, and roach bait stations. These products are pre-filled and sold only in child-resistant packaging. Products containing sulfluramid have not been registered for food or crop uses."

Oct 16, 2002 OPP-2002-0268

Notice of Receipt of Requests to Voluntarily Cancel Certain Pesticide Registrations.
-- Chemsico - Chemsico Roach Control System CS. EPA Reg. No. 009688-00131
-- Griffin - Indoor Roach Bait. EPA Reg. No. 001812-00354
-- Griffin - Finitron Brand Sulfuramid RB MUP.
EPA Reg. No. 001812-00448

EPA intends to grant Griffin and Chemsico's request for voluntary cancellation of these registrations on December 31, 2002. Griffin and Chemsico have waived the 180-day comment period provided for in FIFRA section 6(f). The comment period will be the required 30 days from notice in the Federal Register. After the registrations are canceled, EPA will permit Griffin to sell and distribute Registration 001812- 00448, Finitron Brand Sulfluramid RB MUP until July 25, 2003, and Registration 001812-00354, Indoor Roach Bait until December 31, 2003, and permit Chemisco to sell and distribute Registration 009688-0013, Chemsico Roach Control System CS until December 31, 2003 and permit Chemisco to sell and distribute Registration 009688-0013, Chemsico Roach Control System CS until December 31, 2003.

March 6, 2002 na
  • Requests to voluntarily cancel certain pesticide registrations:
  • FMC Corp. First Line Termite Bait. EPA Reg. No. 000279 LA-95-0014
  • FMC Corp. Firstline GT Plus Termite Bait Station. EPA Reg. No. 000279 LA-98-0010
  • S.C. Johnson & Son. Raid Max Ant Bait. EPA Reg. No. 004822-00356
  • S.C. Johnson & Son. Raid Double Control Ant Baits. EPA Reg. No. 004822-00508
Sept 26, 2001 FIFRA-HQ- 2001-0003
  • Requests to voluntarily cancel certain pesticide registrations:
  • FMC Corp. Firstline GT Plus Termite Bait Station. EPA Reg. No. 000279 LA-98-0010
  • Whitmire. Pro-Control Roach Bait. EPA Reg. No. 000499-00460
  • Griffin. GX-071 Technical. EPA Reg. No. 001812-00327
  • S.C. Johnson & Son. Raid Max Roach Bait. EPA Reg. No. 004822-00355
Aug 22, 2001 na

WHITMIRE - Request to Voluntarily Cancel pesticide registration for Pro-Control Roach Bait.


Systematic Name 1-Octanesulfonamide, N-ethyl-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-
N-Ethylheptadecafluorooctanesulphonamide
Classification Code Agricultural Chemical
Insecticide
Uncoupling agents
Synonyms AI 3-29757
AI3-29757
Alstar (pesticide)
BRN 2317462
EINECS 223-980-3
EPA Pesticide Chemical Code 128992
Finitron
GX 071
Mirex S
N-Ethyl-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-1-octanesulfonamide
N-Ethylperfluorooctanesulfonamide
N-Ethylperfluorooctylsulfonamide
Sulfluramid
Ref: ChemIDplus at Toxnet.
 
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