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Adverse
Effects
Abstracts
ACTIVITY:
Fungicide, Insecticide (phenylsulfamide)
CAS Name:
1,1-dichloro-N-[(dimethylamino)sulfonyl]-1-fluoro-N-(4-methylphenyl)methanesulfenamide
Structure:
Adverse
Effects:
Body
Weight Decrease
Bone - including
Arthrogryposis
Cancer: Likely to be Carcinogenic
to Humans - THYROID
Clastogenic
Cytotoxic
Endocrine: Thyroid
Eye
Kidney
Liver
Reproductive/Developmental
Thyroid
Environmental:
Water-sediment
systems. A hydrolysis study demonstrated
that tolylfluanid was hydrolyzed into DMST [dimethylaminosulfotoluidine],
fluoride ion, chloride ion, sulfur
and carbon dioxide. |
Regulatory
Information
(only comprehensive for the US) |
US
EPA Registered: |
Yes |
US
EPA PC Code: |
309200 |
California
Chemical Code |
3542 |
US
Tolerances: |
CFR
180.584
|
FDA
LMS Code: |
649 |
Registered
use in
(includes only a limited list of countries)
|
Australia,
Denmark, Finland, Germany, Hungary, New Zealand, Tanzania, UK,
US |
US
Maximum Residue Levels permitted
in food commodities
|
On
September 25, 2002, US EPA established an import
tolerance for residues of tolylfluanid in or on imported
Apple,
Grape, Tomato, Hop |
Other
Information |
Molecular
Formula: |
C10H13Cl2
F N2O2S2 |
Manufacturers: |
Bayer |
Other
Names: |
Tolylfluanid
Tolyfluanid
Tolyfluanide
Tolylfluanide [ISO-French]
Euparen M
Euparen Multi
AI3-27470
BAY 49854
BAY 5212
BAY 5712a
BRN 2949607
Bayer 49854
Bayer 5712a
Kue, 13183b |
Manufacture
site: |
GERMANY:
Bayer, Bayerwerk, Dormagen |
Of
special interest: |
PAN
Data |
2005
(released May 25, 2005) - Conclusion regarding the peer review
of the pesticide risk assessment of the active substance tolylfluanid
- updated
-
Conclusion/Summary
(3 pages)
- Final addendum
to the Draft Assessment Report (206 pages)
- Comments on
the draft assessment report (53 pages)
- Reporting
table (105 pages)
- EPCO expert
meeting review reports (66 pages)
- Evaluation
table (32 pages)
|
2002
- Pesticide residues in food - 2002. Report of the Joint Meeting
of the FAO Panel of Experts on Pesticide Residues in Food
and the Environment and the WHO Core Assessment Group on Pesticide
Residues. Rome, Italy. 16- 25 September 2002. ISBN 92-5-104858-4.
http://www.fluorideaction.org/pesticides/tolylfluanid.fao.2002.pdf
Read
the section on the concentration of fluoride in bone and
teeth which increased in a dose related manner.
The report states, "The release
of the fluoride ion and its distribution in the body have
not been clearly characterized (page 254-255)."
In a discussion on water sediment systems, "Another
hydrolysis study demonstrated that tolylfluanid
was hydrolyzed into DMST, fluoride
ion, chloride ion, sulfur and carbon dioxide (page
262)."
The
study also states, "Studies that would provide information
useful for continued evaluation of the compound
• Further characterization of
the distribution and excretion of fluoride and thiazolidine-2-thione4-carboxylic
acid, particularly in milk (page
257)"
On
September 25, 2002, US EPA approved tolerances for tolylfluanid
for 4 imported commodities. In its Final Rule, EPA cited
several bone effects. However, EPA
never discussed fluoride concentrations. (See Federal
Register below).
|
September
2002 -
US EPA Pesticide Fact
Sheet. Reason for Issuance: Import
Tolerance. |
Public
Release Summary. Australia National Registration Authority (NRA)
for Agricultural and Veterinary Chemicals. |
August
1999: European Commision, Consumer Policy and Consumer Health
Protection, Committee Report. Table
5: Pesticides found most often in
the national monitoring programmes in Belgium, France, Netherlands,
Finland, and Norwary included Tolyfluanid. Also available at:
http://www.pestlaw.com/x/international/EC-19990800A.html |
Abstracts |
August,
2001 - IR-4
New Products/Transitional Solution List -
This list contains brief descriptions of numerous new pest control
materials that have been introduced over the last several years.
Additionally, it contains information on some "older"
crop protection chemicals that are believed to have room for
new uses. This List includes:
Tolyfluanid |
April
2000 -
Food and Drug Administration
Pesticide Residue Monitoring. -
Table 3. Pesticides detectable by methods used in 1999 regulatory
monitoring. |
October
2001 - Glossary
of Pesticide Chemicals. A listing
of pesticides subject to analysis of residues in foods and feeds
by the US Food and Drug Administration. |
In
2001, Tolylfluanid ranked 9th out of the ten most frequently
found pesticides in fruits and vegetables. There were 151 samples
with residues at or above reporting level.
Ref:
September 2002 Report
of Pesticide Residue Monitoring Results of the Netherlands for
2001. Inspectorate
of Health Protection, Commodities and Veterinary Public Health
Food Inspection Service Den Haag - Amsterdam Hoogte Kadijk 401
1018 BK Amsterdam The Netherlands |
US
Federal Register |
Date
Published |
Docket
Identification Number |
Details |
Jan 6,
2005 |
OPP-2004-0294 |
Registration
Applications for Pesticide
Products
Containing Active Ingredients Not Included in any Previously
Registered Products.
Product
Name:
File Symbol: |
Applicant:
|
Use: |
%
Active Ingredient in product: |
Preventol
A5-S
39967-UO |
Lanxess
Corporation,
100 Bayer Road,
Pittsburg, PA 15025. |
Antifoulant paint product. |
98.1%
|
Micron
Extra P - Blue
2693-ERU |
International
Paint, Inc.,
2270 Morris Avenue,
Union, NJ 07083. |
Antifoulant
paint product. |
1.96%
|
Ultra
P - Blue
2693-ERL |
International
Paint, Inc.,
2270 Morris Avenue,
Union, NJ 07083. |
Antifoulant
paint product. |
1.64% |
|
Sept
25, 2002 |
OPP-2002-0216 |
BAYER
- Pesticide
Tolerances
- Classified as "Likely
to be carcinogenic to humans," EPA
approves Pesticide
Tolerances in or on
imported apple, grape, hop, tomato.
FINAL RULE.
- |
Approved
Tolerances |
Bayer's
Tolerance petition of Aug 11, 1997 |
Apple |
5.0
ppm |
same |
Grape
|
11
ppm |
5.0
ppm |
Hop |
30
ppm |
same |
Tomato |
2.0
ppm |
1.0
ppm |
-- Classification:
``Likely to be carcinogenic to humans''
by the oral route, based on thyroid tumors in high-dose male
and female rats. The FQPA SF Committee further recommended
a linear low-dose extrapolation approach for the quantification
of human cancer risk based on the thyroid tumors in rats.
Q1*
= 1.59 x 10-\3\ based upon male rat thyroid adenomas and/or
carcinomas combined.
-- The cancer risk estimate is 1.2
x 10-\6\ for the general U.S. population (1.2
cancers per million).
-- Prenatal developmental toxicity/rabbit LOAEL = 70 mg/kg/day
based on
increased malformations (arthrogryposis of front extremities
and small orbital cavity/folded retina) and variations (floating
ribs and accelerated ossification).
-- 2-Generation reproduction and fertility effects (rat):
Parental/systemic- LOAEL = 15.9-21.5 mg/ kg/day, based
on hardened crania of P generation animals
-- Combined chronic toxicity/carcinogenicity rodents (rat):
NOAEL = 18.1/21.1 mg/ kg/day (M/F); LOAEL = 90.1/105.2 mg/
kg/day (M/F), based on skeletal changes.
Evidence of thyroid follicular cell adenomas and/or carcinomas
in high- dose males and females.
-- Combined chronic toxicity/carcinogenicity rodents (rat):
NOAEL = 20/20 mg/kg/ day (M/F); LOAEL = 80/110 mg/kg/day (M/F),
based on bone hyperostosis in males and females Evidence of
thyroid follicular cell adenomas and/or carcinomas in high-
dose males and females.
-- Carcinogenicity rodents (mouse): NOAEL = 76.3/123.9 mg/kg/day
(M/F) LOAEL = 375.8/610.8 mg/kg/day (M/F), based
on skeletal, liver, and kidney changes. No evidence
of carcinogenicity.
-- Non-guideline (rat) thyroid function: Thyroid-stimulating
hormone
levels significantly
increased (168-425%) in high-dose males and females. Slightly
increased T3 levels in males rats above 119.3 mg/ kg/day.
-- Acute oral neurotoxicity/rat. LOAEL = 150 mg/kg/day based
on FOB effects (pilorection, decreased
activity, gait abnormalities, decreased body temperature,
and/or decreased rearing). |
Aug 11, 1997 |
PF-755 |
BAYER
- Petition
for pesticide tolerances. Bayer requested establishing
import tolerances for
residues of the fungicide Tolylfluanid in or on the raw agricultural
commodities apples and grapes at 5.0 ppm, hops at 30 ppm and
tomatoes at 1.0 ppm. |
|