Trichlorotrifluoromethane (Freon 113)
CAS No. 76-13-1

 
 

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ACTIVITY: Solvent, US EPA List 2 Inert (Halogenated organic)

Structure:

Regulatory Information
(only comprehensive for the US)
US EPA Registered: Yes
List 2 Inert 
California Chemical Code 2960 
Other Information
Molecular Formula: C2-Cl3-F3  
Manufacturers: Allied Signal
DuPont 
Other Names: 1,1,2-Trichloro-1,2,2-trifluoroethan
CFC-113
Freon 113
TCTFE 
Of special interest:
PAN Data 
TOXNET profile from Hazardous Substances Data Base  
May 1998 - IRIS - Integrated Risk Information System - US EPA 
2000 US Toxic Release Inventory - Brief summary
1998 - In this report Trichlorotrifluoromethane (or 1,1,2-trichloro-1,2,2-trifluoroethane) was identified as: "Dangerous for the ozone layer." The report, entitled Examples of substances requiring particular attention, was issued by the Swedish National Chemicals Inspectorate in collaboration with the Swedish Environmental Protection Agency and the Swedish National Board of Occupational Safety and Health. NATIONAL CHEMICALS INSPECTORATE. Order No 510 622. Second, revised edition, 1998. See list of the specific Fluorine and organofluorine pesticides cited in the report. 

Adverse Effects:

Brain
CNS
Heart
Liver
Lung
Tremors

Environmental Effects:

Class 1 Ozone Depleting Substance. Lifetime of Global Warming Potential: 85 years

Very resistant to chemical and biological degradation and likely to be a persistent contaminant if it reaches groundwater.

Bioconcentration in organisms is low to moderate.

Accidental Death:

A worker died while assisting three workers who were cleaning out a Freon 113 vapor degreaser at a chemical fuel plant.


US EPA List of Inerts. This substance is on List 2.
Note: US EPA allows so-called "Inert" ingredients to be commonly mixed with the "active" pesticidal ingredient to create a formulated pesticide product. According to EPA, "The term `inert' is not intended to imply nontoxicity; the ingredient may or may not be chemically active." "Inert" ingredients include solvents, emulsifiers, spreaders, and other substances mixed into pesticide products to increase the effectiveness of the active ingredients, make the product easier to apply, or to allow several active ingredients to mix in one solution. Both US EPA and California Department of Pesticide Regulation require pesticide manufacturers to identify inert ingredients in their products but do not disclose this information to the general public because the pesticide industry considers product formulations trade secrets, protected by law and by the US EPA. The US EPA category of Inerts (as of September 2003):

List 1 - Of Toxicological Concern
List 2 - Potentially Toxic / High Priority for Testing
List 3 - Of Unknown Toxicity
List 4A - Generally Regarded as Safe
List 4B - EPA states it has Sufficient Information to Reasonably Conclude that the Current Use Pattern in Pesticide Products will not Adversely Affect Public Health or the Environment
List 4 (all)

See good report: Toxic Secrets": "Inert" Ingredients in Pesticides 1987-1997, published by Northwest Coalition for Alternatives to Pesticides.


Fluorocarbon vapors are 4 to 5 times heavier than air. Thus high concn tend to accumulate in low-lying areas, resulting in hazard of inhalation of concentrated vapors, which may be fatal. /Fluorocarbons/
[Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994. 1195]

Average Daily Intake: The average daily in take of 1,1,2-trichloro-1,2,2-trifluoroethane in air, (assume 13-31 parts/trillion(1,2)) is 2.0-4.8 ug/day(SRC).
[(1) Fabian P et al; J Geophys Res 90: 13091-3 (1985) (2) Brodzinsky R, Singh HB; pp. 23-184 in Volatile Organic Chemicals in the Atmosphere: An Assessment of Available Data Menlo Park, CA: SRI International (1982)]

NIOSH (NOES Survey 1981-1983) has statistically estimated that 250,773 workers (79,790 of these are female) are potentially exposed to 1,1,2-trichloro-1,2,2-trifluoroethane in the US(1). Occupational exposure to 1,1,2-trichloro-1,2,2-trifluoroethane may occur through inhalation and dermal contact with this compound at workplaces where it is produced or used. Due to its long atmospheric residence time, the general population is exposed to 1,1,2-trichloro-1,2,2-trifluoroethane through inhalation of ambient air. Monitoring data indicate that the general population may also be exposed to 1,1,2-trichloro-1,2,2-trifluoroethane via ingestion of contaminated water, and via inhalation and dermal contact with this compound and other consumer products containing this compound(SRC).
[(1) NIOSH; National Occupational Exposure Survey (NOES) (1983)]

Average Daily Intake: The average daily in take of 1,1,2-trichloro-1,2,2-trifluoroethane in air, (assume 13-31 parts/trillion(1,2)) is 2.0-4.8 ug/day(SRC).
[(1) Fabian P et al; J Geophys Res 90: 13091-3 (1985) (2) Brodzinsky R, Singh HB; pp. 23-184 in Volatile Organic Chemicals in the Atmosphere: An Assessment of Available Data Menlo Park, CA: SRI International (1982)]

Ref: Hazardous Substances Data Bank for 1,1,2-TRICHLORO-1,2,2-TRIFLUOROETHANE CASRN: 76-13-1.
http://www.fluorideaction.org/pesticides/trichlorotrifluorome.toxnet.htm


US Federal Register
Date Published Docket Identification Number Details
June 24, 1998 OPP- 36192 US EPA List 2 Inert; Ingredient in Pesticide Products.
 
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