Abstract
One-month old female Swiss albino mice were given 60 ppm and 120 ppm F– (from NaF) in their drinking water for 30 days to study effects of fluoride on neurotransmitter enzymes (AchE, BchE), anti-oxidant enzymes (SOD, CAT), and lipid peroxidation (MDA) in brain (hippocampus), liver, and gastrocnemius muscle. Activities of AchE and BchE showed a concentration-dependent decrease in all the tissues studied, which was highly significant in liver and muscles. Superoxide dismutase (SOD) and catalase (CAT) also showed a significant concentration dependent decrease in all the tissues, which was highly significant for CAT at 120 ppm in liver and muscles. Malondialdehyde (MDA), however, showed a significant concentration dependent increase in gastrocnemius muscle, but in brain and liver it had an initial decrease at 60 ppm F– that changed to a significant increase at 120 ppm. Ascorbic acid exhibited significant concentration-dependent increases in all the tissues examined. Total protein showed a concentration dependent decrease in brain and muscles but an increase in liver. The results of the study indicate that elevated fluoride in drinking water affects not only mammalian neurotransmitter functions but also antioxidant systems.
-
-
Gaseous Anesthetics.
Introduction The history of anesthesia is a relatively recent one; if one begins with the analgesia dentist, Horace Wells, who discovered the used nitrous oxide during a dental extraction in the early 1800s. The first public showing of anesthesia occurred in October 1846, when ether was used to prevent pain during surgery
-
Systematic impacts of fluoride exposure on the metabolomics of rats.
Highlights The risk of chronic endemic fluorosis exists in many countries and regions. Comprehensive metabolomic analysis was used to study the effects of fluoride. Multivariate statistics were used to detect metabolite profile changes. Fluoride exposure caused amino acid, fatty acid, and energy metabolism disorders. Fluoride exposure caused oxidative stress,
-
Decreased learning ability and low hippocampus glutamate in offspring rats exposed to fluoride and lead.
Fluoride (F) and lead (Pb) are two common environmental pollutants which are linked to the lowered intelligence, especially for children. Glutamate, a major excitatory neurotransmitter in the central nervous system, plays an important role in the process of learning and memory. However, the impact of F and Pb alone or
-
Effect of exercise on microglial activation and transcriptome of hippocampus in fluorosis mice.
Highlights Exercise alleviated fluoride-induced activation of microglia in hippocampus. Exercise altered the expressions of 670 genes in hippocampus of fluorosis mice. Neuroactive ligand-receptor interaction pathway involved in the regulation of exercise on neuro-fluorosis. Fluorosis is a widespread endemic disease. Reports have shown that high fluoride causes the dysfunction of central
-
[Study of the mechanism of neurone apoptosis in rats from the chronic fluorosis].
Objective: Study the mechanism of action chronic fluorosis in neurones. Methods: Terminal deoxyribo-nucleotide transferase-mediated dUTP-biotin nick end labeling (TUNEL) and flow cytometry (FCM) were used to observe changes of apoptosis in cerebral cells in chronic fluorosis in rats. Results: TUNEL results show non-random expression of DAB positive stain apoptosis cells which appear
Related Studies :
-
-
-
NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
-
Fluoride & IQ: 76 Studies
Note: See the Updated list of fluoride IQ studies at https://fluoridealert.org/researchers/fluoride-iq-studies/the-fluoride-iq-studies/ • As of July 18, 2022, a total of 85 human studies have investigated the relationship between fluoride and human intelligence. • Of these investigations, 76 studies have reported that elevated fluoride exposure is associated with reduced IQ in humans. • The studies
-
Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
-
Fluoride Affects Learning & Memory in Animals
An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out
-
Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are 78 studies reporting reduced IQ (75 studies with children and 3 studies with adults) and several on the impaired learning/memory in animals. And there are studies which link
Related FAN Content :
-