Abstract
Radioimmunologic study of thyrotropin and thyroid hormones in the blood of those engaged in fluorine production showed moderate functional changes of the hypophysis-thyroid gland system, not accompanied by clinical manifestations of hypo- or hyperthyreosis and caused by disorders of the regulatory chain and fluorine impact on thyroid hormones’ metabolism at the level of target cells. Elevation of calcitonin concentration in workers’ blood indicated stimulation of thyroid gland parafollicular cells. Phase states in the hypophysis-thyroid gland system were detected along with the dependence of some hormones’ concentration on the duration of workers’ contact with fluorine compounds and the stage of fluorosis.
-
-
Fluoride caused thyroid endocrine disruption in male zebrafish (Danio rerio)
Highlights Fluoride inhibited the growth of male zebrafish. Fluoride injured the histological structure of thyroid in male zebrafish. Fluoride changed T3 and T4 levels, and genes transcriptions involved in HPT axis. Excessive fluoride in natural water ecosystem has the potential to detrimentally affect thyroid endocrine system, but little is known
-
Ameliorative effect of resveratrol against fluoride-induced alteration of thyroid function in male wistar rats
Resveratrol (3,4,5-trihydroxystilbene), a polyphenol and well-known natural antioxidant has been evaluated for its protective effect against fluoride-induced metabolic dysfunctions in rat thyroid gland. Fluoride, the most abundant anions present in groundwater throughout the world, creates a major problem in safe drinking water and causes metabolic, structural, and functional injuries in
-
Is water fluoridation a hidden cause of obesity? Histological study on thyroid follicular cells of albino rats
Introduction: Fluoride in drinking water is known to exert both beneficial and detrimental effects on health. When consumed in excess, it is known to cause adverse effects including dental fluorosis, hip fracture, bone cancer, lower intelligence, and kidney toxicity plus goiter. Aim: This study was carried out to determine the histological
-
Fluoride-induced thyroid dysfunction in rats: roles of dietary protein and calcium level.
To assess the roles of dietary protein (Pr) and calcium (Ca) level associated with excessive fluoride (F) intake and the impact of dietary Pr, Ca, and F on thyroid function, 144 30-day-old Wistar albino rats were randomly allotted to six groups of 24 (female:male = 1:1). The six groups were
-
Comparison of the effects of various agents on thyroidal adenyl cyclase activity with their effects on thyroid hormone release
Intact mouse thyroid glands were used to measure the formation of cyclic [3H]AMP from [3H]adenine, and the release of thyroidal iodine. These two parameters of thyroid activity responded to similar concentrations of thyroid-stimulating hormone (TSH). Both were stimulated by prostaglandin E1, although the response was always very much less than
Related Studies :
-
-
-
Fluoride's Impact on Thyroid Hormones
Up through the 1950s, doctors in Europe and South America prescribed fluoride for this purpose in patients with hyperthyroidism. (Merck Index 1968). Fluoride was selected as a thyroid suppressant based on findings dating back to the mid-19th century that fluoride is a goitrogen (a substance that can cause goiter). When used as
-
Fluoride Aggravates Thyroid Damage Caused by Excess Iodine Intake
Chinese researchers have found that the combination of excess fluoride with excess iodine caused greater reductions in IQ, or greater increases in goitre than either scenario by itself.
-
Fluorine in the Aetiology of Endemic Goitre
The distribution of endemic goitre in the Punjab and in England is related to the geological distribution of fluorine and to the distribution of human dental fluorosis (mottled enamel). Inquiry showed the presence of dental fluorosis among school-children in two areas of Somerset where two previous observers had recorded a high incidence of goitre, and the absence of dental fluorosis in an adjoining area selected as control where endemic goitre was absent.
-
Is fluoride-induced hyperthyroidism a cause of psychosis among East African immigrants to Scandinavia?
When people with a compensated fluoride-induced hypothyroidism move to a low-fluoride area, the fluoride-induced inhibition of the production of thyroid hormones ceases. In Scandinavia, the dietary intake of iodine is usually quite high due to iodized table salt and easy access to marine fish. Under these conditions, the elevated capacity for production of thyroid hormones may result in hyperthyroidism.
-
Fluoride Exposure Aggravates the Impact of Iodine Deficiency
A consistent body of animal and human research shows that fluoride exposure worsens the impact of an iodine deficiency. Iodine is the basic building block of the T3 and T4 hormones and thus an adequate iodine intake is essential for the proper functioning of the thyroid gland. When iodine intake is inadequate during infancy and
Related FAN Content :
-