Abstract
The aim of the study was to evaluate relationship between infertility and the histological structure of the testes following the subcutaneous administration of different doses of sodium fluoride (5, 10, 20 and 50 mg/kg/day), for 100 days, to groups of six male albino rabbits; the six control animals were given 1 cc distilled water/kg b.w./day for the same length of time. Deficient maturation and differentiation of the spermatocytes and an increase in the amount of interstitial tissue were found in the experimental animals. In the higher dosage groups, spermatogenesis stopped and the seminiferous tubules became necrotic. The study thus established the existence of a definite relationship between fluorosis and testicular damage.
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Evaluation of vitamin E and calcium effects on fluoride toxicity-induced fertility impairment
Chronic fluoride (Fl) toxicity is a serious public health problem globally where drinking water contains more than 1 ppm of Fl. Sodium fluoride (NaF) produced male reproductive system toxicity. The aim of the present study was to evaluate the amelioration of Fl toxicity-induced fertility impairment by vitamin E and calcium
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Fluoride exposure changed the structure and the function of sperm in the testis and epididymis of male rats.
This study systematically investigated the effects of fluoride ion (F)exposure on the male reproductive organ and on spermatogenesis. Twenty male rats were divided into two groups of 10 and treated with 0 or 150 mg F/L in drinking water. After 70 days, the body weight, organ coefficients of the testis
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Co-exposure to fluoride and arsenic disrupts intestinal flora balance and induces testicular autophagy in offspring rats.
Highlights F and As exposure caused an imbalance in the intestinal flora of rats. F and As exposure caused alterations in autophagic flux, which were positively correlated with SMB53 and Anaerostipes. F and As exposure caused alterations in reproductive hormones, which were negatively correlated with Parabacteroides. Under experimental conditions,
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Impact of 12-week ingestion of sodium fluoride on agression, sexual behavior, and fertility in adult male rats.
Ingestion of sodium fluoride at 100 and 300 ppm in drinking water for 12 weeks by adult male Sprague-Dawley rats was investigated for effects on territorial aggression, sexual behavior, and fertility. Body weight and absolute and relative testes weights were not affected, but the average weights of epididymis, ventral prostate,
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[Excessive fluoride increases the expression of osteocalcin in the mouse testis].
OBJECTIVE: To observe the influence of excessive fluoride on the levels of osteocalcin and testosterone in the testis of the male mouse. METHODS: Twenty-four C57BL/6J male mice were equally randomized into a normal control and a fluorosis model group, the former fed on distilled water while the latter on a solution of sodium
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Fluoride's Effect on the Male Reproductive System -- In Vitro Studies
Carefully controlled in vitro studies have found that direct exposure of fluoride to the testes or semen inhibits testosterone production and damages sperm. While researchers have known since the 1930s that mega concentrations of fluoride can completely (but reversibly) immobilize sperm, it was not until the 1970s and 1980s that researchers found that relatively modest concentrations of fluoride could cause damage prior to complete immobilization.
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Fluoride's Effect on Male Reproductive System: Animal Studies
Over 60 studies on animals (including rats, mice, roosters, and rabbits) have found that fluoride adversely impacts the male reproductive system. These studies have repeatedly found the following effects: (1) decreases in testosterone levels; (2) reduced sperm motility; (3) altered sperm morphology; (4) reduced sperm quantity; (5) increased oxidative stress; (6) and reduced capacity to breed.
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Fluoride's Effect on Male Reproductive System -- The "Sprando/Collins" Anomaly
In contrast to the findings of over 60 animal studies from other research teams, a series of studies by FDA researchers Sprando & Collins reported virtually no evidence of reproductive toxicity among animals treated with very high levels of fluoride exposure. The reasons for this discrepancy remains unclear. Excerpts from Sprando/Collins' Studies: "This study
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Fluoride's Effect on Male Reproductive System - Human Studies
Consistent with in vitro and animal research, studies of human populations have reported associations between fluoride exposure and damage to the male reproductive system. Most notably, a scientist at the Food & Drug Administration reported in 1994 that populations in the United States with more than 3 ppm fluoride in their water had lower "total fertility rates" than populations with lower fluoride levels.
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