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Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Fluoride exposure and sleep patterns among older adolescents in the United States: a cross-sectional study of NHANES 2015–2016.

December 9, 2019 | Environmental Health | Malin AJ, Bose S, Busgang SA, Gennings C, Thorpy M, Wright RO, Wright RJ, Arora M. | [Epub ahead of print] https://doi.org/10.1186/s12940-019-0546-7
Abstract Background Fluoride from environmental sources accumulates preferentially in the pineal gland which produces melatonin, the hormone that regulates the sleep-wake cycle. However, the effects of fluoride on sleep regulation remain unknown. This population-based study examined whether chronic low-level fluoride exposure is associated with sleep patterns and daytime sleepiness among older adolescents in the United States (US). Method This cross-sectional study utilized data from t

Comparative efficacy of a hydroxyapatite and a fluoride toothpaste for prevention and remineralization of dental caries in children.

December 9, 2019 | BDJ Open | Amaechi BT, AbdulAzees PA, Alshareif DO, Shehata MA, de Carvalho Sampaio Lima PP, Abdollahi A, Kalkhorani PS, Evans V. | 5:18. doi:10.1038/s41405-019-0026-8
Abstract Objective This in situ study compared the effectiveness of two toothpastes containing hydroxyapatite or 500 ppm fluoride in promoting remineralization and inhibiting caries development. Materials and methods Two enamel blocks (human primary teeth), one sound and one with artificially-produced caries lesion, were exposed to toothpaste containing either 10% hydroxyapatite or 500 ppm F- (amine fluoride) via intra-oral appliance worn by 30 adults in two-arm double blind randomized

Co-exposure to Arsenic-Fluoride Results in Endoplasmic Reticulum Stress-Induced Apoptosis Through the PERK Signaling Pathway in the Liver of Offspring Rats.

November 25, 2019 | Biological Trace Element Research | Dong N, Feng J, Xie J, Tian X, Li M, Liu P, Zhao Y, Wei C, Gao Y, Li B, Qiu Y, Yan X. | doi: 10.1007/s12011-019-01975-1. [Epub ahead of print]
References 1. Wang SX, Wang ZH, Cheng XT, Li J, Sang ZP, Zhang XD, Han LL, Qiao XY, Wu ZM, Wang ZQ (2007) Arsenic and fluoride exposure in drinking water: children’s IQ and growth in Shanyin County, Shanxi Province, China. Environ Health Perspect 115(4):643–647PubMedPubMedCentralCrossRefGoogle Scholar 2. Rocha-Amador D, Navarro ME, Carrizales L, Morales R, Calderón J (2007) Decreased intelligence in children and exposure to fluoride and arsenic in drinking water. Cadernos