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Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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The impact of sevoflurane anesthesia on postoperative renal function: a systematic review and meta-analysis of randomized-controlled trials.

August 18, 2020 | Canadian Journal of Anesthesia/Journal Canadien d | Rakesh V Sondekoppam, Karim H Narsingani, Trent A Schimmel, Brie M McConnell, Karen Buro, Timur JP Ozel | [Epub ahead of print]
References Abbvie Ltd. ULTANE® (sevoflurane) volatile liquid for inhalation. Available from URL: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020478s030lbl.pdf (accessed June 2020).  Mazze RI. Methoxyflurane revisited: tale of an anesthetic from cradle to grave. Anesthesiology 2006; 105: 843-6. CAS  PubMed  Google Scholar  Gentz BA, Malan TP Jr. Renal toxicity with sevoflurane: a storm in a teacup? Drugs 2001; 61: 2155-62. CAS  PubMed  Google Scho

The future is now—it’s time to rethink the application of the Global Warming Potential to anesthesia

May 8, 2019 | Canadian Journal of Anesthesia/Journal Canadien d | Timur J.-P. Ozelsel MD, Rakesh V. Sondekoppam MD & Karen Buro PhD | 66:1291–1295.
All volatile anesthetic agents are fluorocarbons and variably potent greenhouse gases (GHG).1 As a chlorofluorocarbon (CFC), isoflurane also has ozone depleting potential (as does nitrous oxide [N2O]), while sevoflurane and desflurane, being hydrofluorocarbons (HFC), do not.1 The global emission of HFCs increased 128% from 1990 to 2005 and is projected by 2030 to increase a further 336% compared with 2005 emissions.2 The Montreal Protocol is an international treaty agreed upon in 1987 with t

Effects of Fluoride on Oxidative Stress Markers of Lipid, Gene, and Protein in Rats.

August 13, 2020 | Biological Trace Element Research | Zhong N, Yao Y, Ma Y, Meng X, Sowanou A, Pei J. | [Epub ahead of print]
References Kurdi MS (2016) Chronic fluorosis: the disease and its anaesthetic implications. Indian J Anaesth 60(3):157–162. https://doi.org/10.4103/0019-5049.177867 CAS  Article  PubMed  PubMed Central  Google Scholar Patel PP, Patel PA, Zulf MM, Yagnik B, Kajale N, Mandlik R, Khadilkar V, Chiplonkar SA, Phanse S, Patwardhan V, Joshi P, Patel A, Khadilkar AV (2017) Association of dental and skeletal fluorosis with calcium intake and serum vitamin D concentra

Fluoride metabolism: its significance in water fluoridation.

March 1956 | The Journal of the American Dental Association | Harold C. Hodge | 52(3):307-314.
Excerpt The purpose of this report is the review of the present knowledge of the metabolism of fluorides, particularly in the human body, and the use of this knowledge in estimating the factors of safety in water fluoridation. In this discussion, many of the biological effects of fluorides (purported or well-established) will receive no mention. On the other hand, there are a few important biological effects of fluorides so well studied that there is an established relation between the effect a

A Meta-Analysis of Stressors from the Total Environment Associated with Children’s General Cognitive Ability

July 29, 2020 | International Journal of Environmental Research and Public Health | Frances M. Nilsen, Jazmin D.C. Ruiz, and Nicolle S. Tulve. |
Excerpt: page 11 ... Fluoride was observed to have the greatest increase in impacting cognitive ability (OR = 1.40, p  0.05) and it is often reported to affect memory and cause cognitive deficits [241]. (our emphasis) Reference 241 Smith, P.W. Memory Maintenance and Cognitive Decline. In Anti-Aging Therapeutics Volume XVI; Klatz, R., Goldman, R., Eds.; A4M Publications: Chicago, IL, USA, 2015.