Increased fluoride content in the femur growth plate and cortical bone of uremic rats
September 2000
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Pediatric Nephrology
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Mathias RS, Amin U, Mathews CH, Denbesten P.
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14(10-11):935-9
In summary, we demonstrate an increased F– content in the growth plate region of the femur at 4 weeks and 8 weeks, and in cortical bone at 8 weeks, in rats with experimental
CRI. We hypothesize that elevated serum F– levels might contribute to the disturbances in mineral ion homeostasis that are observed in patients with CRI. This is of particular concern since the incidence of dental fluorosis has increased due to increased F– uptake from multiple fluoridated sources [24]. The ubiquitous