A 79-year-old lady presented with a history of diffuse sero-negative arthritis dating from early adulthood. Numerous investigations and therapies had failed to provide any significant benefit and both knees and a hip had been replaced when initially seen a year ago. On questioning at that time, she admitted to daily drinking at least six cups of black tea since childhood. She lives in a retirement village where there has not been water fluoridation since 1994. However, her fasting fluoride r
EXCERPTS
... Generally, many studies report Rab proteins as molecules present in the CNS and their specific roles. Although marked differences distinguish the neuronal function between the ENS [Enteric Nervous System] and CNS, their similarities allow the use of some principles established for the brain environment to be reapplied in the enteric context 38. Several cellular processes can be altered and promote the enteric neuronal alterations caused by F effects through mechanisms involving the
