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Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Ossification of the posterior longitudinal ligament and fluorosis

May 1992 | Journal of Bone and Joint Surgery | Rao BS, Taraknath VR, Sista VN. | 74-B(3):469-70.
There is only one report of ossification of the posterior longitudinal ligament (OPLL) in patients suffering from fluorosis. Deshpande, Dinakarand Reddy (1976) mention an association with fluorosis in 14 of 26 cases. OPLL is not mentioned in two reviews of fluorosis (Jolly 1981; Reddy and Reddy 1987). Patients. In our neurological service, we saw 15 cases of OPLL in one year, allpresenting with spinal compression. They accounted for about 1 .5% of all spinal cases. Ten of them had associated

Thoracic myelopathy from coincident fluorosis and epidural lipomatosis

March 2010 | Canadian Journal of Neurological Sciences | Kalia LV, Lee L, Kalia SK, Pirouzmand F, Rapoport MJ, Aviv RI, Mozeg D, Symons SP. | 37(2):276-8.
Skeletal fluorosis is rare in North America. It can present with back pain and extremity weakness. Immobilization of the spine and the extremity joints can occur. It is usually caused by abnormally increased oral fluoride intake over many years. Epidural lipomatosis is usually caused by idiopathic obesity or corticosteroid use. It has been linked to highly active antiretroviral therapy (HAART) for human immunodeficiency virus (HIV). Fluorosis and epidural lipomatosis are each rare causes of comp

Prevalence and aetiology of juvenile skeletal fluorosis in the south-west of the Hai district, Tanzania–a community-based prevalence and case-control study

February 2013 | Tropical Medicine & International Health | Jarvis HG, Heslop P, Kisima J, Gray WK, Ndossi G, Maguire A, Walker RW. | 18(2):222-9.
Fifty-six cases (34 males, 60.7%) of severe, deforming JSF were identified from the 1263 [691 females (54.7%) 88.0% of the entire village population] that were available for musculoskeletal examination. This represented a prevalence of 4.4% (95% CI, 3.3–5.6). Twenty-four cases of JSF (contained within 10 families) had at least one sibling who was also affected. The prevalence in males was 6.2% (95% CI, 4.2–8.2) and in females 3.1% (95% CI, 1.8–4.4). The age of the cases of JSF identified r

Renal failure and fluorosis

1972 | Journal of the American Medical Association | Juncos LI, Donadio JV Jr. | 222(7):783-5.
It is generally agreed that water fluoridation is safe for persons with normal kidneys. Systemic fluorosis in patients with diminished renal function, however, seems a reasonable possibility. In such patients, fluoride may be retained with resulting higher tissue fluoride levels than in persons with normal renal function.