Fluoride: mode of action.
June 1998
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Bone
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Caverzasio J, Palmer G, Bonjour JP.
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22(6):585-9
Conclusions and Perspectives
The results obtained so far on the cellular mechanism by which fluoride may influence the growth and differentiation of osteoblastic cell lines strongly suggest alteration of one or several G protein-dependent tyrosine phosphorylation process(es), activation of the ERK, and possibly other signaling pathways. There is a controversy of whether enhancement of tyrosine phosphorylation induced by fluoride results from inhibition of tyrosine phosphatase(s) or activation