Fluoridated water is piped to more than one-third of the Canadians1 and nearly three-quarters of the Americans2 who use public water systems. Although fluoride helps prevent dental cavities, some studies have suggested that higher prenatal exposures may affect neurodevelopment.3,4 Those findings make it important to understand exposure levels in general populations. Research published in Environmental Health Perspectives now sheds light on fluoride levels in pregnant women in Canada.5
As part
Fluorine is an indispensable tool in the medicinal chemists’ toolbox. Due to its small size and strong electron-withdrawing property, fluorine is widely used in medicinal chemistry to improve a molecule’s potency and permeability, modulate its pKa and lipophilicity, and control its conformation. Of the 38 small molecule drugs that were approved by the FDA in 2018, 18 contain fluorine. As the C–F bond-dissociation energy (BDE) is very high (typically 109 kcal/mol or above), fluorine is ofte
Abstract
We in situ assessed the influence of natural fluoride concentrations in lotic freshwater ecosystems on diet and morphology of Boana cordobae tadpoles. Two streams were sampled in Argentina: Los Vallecitos stream (LF-LV) and Los Cerros Negros stream (HF-CN) with low and high fluoride levels, respectively. We captured tadpoles of B. cordobae in each stream using nets. Body weight (BW), total length (TL) and body condition (BC) of tadpoles was registered. Food items were identified to
Excerpts
A collaborative project involving:
Republic of Ireland
The Department of Health and Children
Health Services Executive, formerly the health boards:
East Coast Area
Midland Area
Mid Western Area
North Eastern Area
Northern Area
North Western Area
South Eastern Area
Southern Area
South Western Area
Western Area
Northern Ireland
The Department of Health Social Services and Public Safety
Eastern Board
Northern Board
Southern Board
Western Board
WHO Collaborating Centre
