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Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Dose-dependent effect of fluoride on clinical and subclinical indices of fluorosis in school going children and its mitigation by supply of safe drinking water for 5 years: An Indian study.

February 2, 2018 | Environmental Monitoring and Assessment | Khandare AL, Validandi V, Gourineni SR, Gopalan V, Nagalla B. | 189(11):579.
References Das, K., & Mondal, N. K. (2016). Dental fluorosis and urinary fluoride concentration as a reflection of fluoride exposure and its impact on IQ level and BMI of children of Laxmisagar, Simlapal Block of Bankura District, W.B., India. Environmental Monitoring and Assessment, 188(4), 218.CrossRefGoogle Scholar Dean, H.T. (1942). The investigation of physiological effects by the epidemiological method. In F. R. Moulton (Ed.), “Fluorine and dental health,” (pp.23–31

Excessive ER stress and the resulting autophagic flux dysfunction contribute to fluoride-induced neurotoxicity.

February 2018 | Environmental Pollution | Niu Q, Chen J, Xia T, Li P, Zhou G, Xu C, Zhao Q, Dong L, Zhang S, Wang A. | 233:889-899.
from 4. Discussion ... In order to gain a better understanding of the NaF neurotoxicity and its underlying mechanisms, the NaF-treated rats and SH-SY5Y cells were used in the present study. The MWM [Morris water maze test] results showed that exposure of rats to NaF is associated with decreased learning and memory abilities. This is consistent with previous studies where animals exposed to fluoride with similar dosages and duration can also demonstrated different characteristics of neurotoxic

Changed expressions of N-methyl-D-aspartate receptors in the brains of rats and primary neurons exposed to high level of fluoride

January 2018 | Journal of Trace Elements in Medicine and Biology | Wei N, Dong YT, Deng J, Wang Y, Qi XL, Yu WF, Xiao Y, Zhou JJ, Guan ZZ. | 45:31-40.
4. Discussion ... the numbers of Nissl bodies in neurons in the hippocampus and cortex of brains from both adult rats and their pups with fluorosis were lowered. Such reduction in Nissl bodies, showing large granular bodies consisting of rough endoplasmic reticulum with rosettes of free ribosomes carrying out protein synthesis, indicates injury of neurons [23].