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The effects of fluoride on neuronal function occurs via cytoskeleton damage and decreased signal transmission

In conclusion, the effects of NaF on a cell’s survival and integrity suggested that different concentrations NaF had direct toxic effects on the Neuro-2A cell line. NaF not only reduced the expression of select axonal proteins, but also prevented the secretion and delivery of the neurotransmitter glutamate.We found that expression of glutamate and its receptor, NMDAR, decreased with increasing dosages of NaF. Presumably, NaF can influence the generation and functions of axons, and limit