The effects of fluoride on neuronal function occurs via cytoskeleton damage and decreased signal transmission
October 2017
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Chemosphere
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Chen L, Ning H, Yin Z, Song X, Feng Y, Qin H, Li Y, Wang J, Ge Y, Wang W.
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185:589-594.
In conclusion, the effects of NaF on a cell’s survival and integrity
suggested that different concentrations NaF had direct toxic effects
on the Neuro-2A cell line. NaF not only reduced the expression of
select axonal proteins, but also prevented the secretion and delivery
of the neurotransmitter glutamate.We found that expression
of glutamate and its receptor, NMDAR, decreased with increasing
dosages of NaF. Presumably, NaF can influence the generation and
functions of axons, and limit