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Fluoridation of drinking water and chronic kidney disease: absence of evidence is not evidence of absence.

Comment on Effects of fluoridation of community water supplies for people with chronic kidney disease. [Nephrol Dial Transplant. 2007, Oct;22(10):2763-7.] Sir, Ludlow et al. [1] only confirmed that our knowledge of the potential adverse effects of chronic low fluoride supplementation of drinking water on normal or diseased kidneys is insufficient. More than 60 years after water fluoridation, there is no high-level evidence as most published studies are small, have methological de