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Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Chronic fluorides impact on pancreatic islet cells in workers

November-December 1992 | Gigiena i Sanitariia (Hygiene and Sanitation) | Tokar VI, Zyryanova VV, Shcherbakov SV. | pp 42-44.
[T]he analysis of the results obtained and secondary data allow us to conclude that the pancreas is not unaffected during CFI. For the first time we have provided a complex characteristic of insulin, G and C-peptide contents in the blood serum of people during CFI [chronic fluoride intoxication], which evidenced moderate hypoinsulinemia accompanied by normal or slightly elevated G and glucose levels. Hormonal status changes reflect the complex mechanism of direct or indirect fluoride impact on t

Fluorosis–a rare complication of diabetes insipidus.

May 1998 | Indian Pediatrics | Mehta MN, Raghavan K, Gharpure VP, Shenoy R. | 35(5):463-7.
The familial pituitary or central diabetes insipidus (DI) is a relatively rare condition with variable onset, from birth to several years of age and variable severity within a family and in individuals over time(l). Severe dehydration and growth retardation, though rare are known compilations of DI. However, dental fluorosis as a complication of DI has been described in the literature only in three families(2,3). Further, severe crippling deformities due to skeletal fluorosis has not been report

Red blood cell glucose metabolism in human chronic fluoride toxicity

1991 | Bulletin of Environmental Contamination and Toxicology | Saralakumari D, Rao PR. | 47:834-39.
Fluoride is a well known inhibitor of many enzyme systems in vitro (Shahed etal. 1979; Messer 1984). The most widely studied classic example of fluoride inhibition is its potent inhibition of glycolysis, specifically its action on the enzyme enolase (Warburg and Christian 1941; Shearer and Suttie 1970; Repaske and Suttie 1979; Shahed et al. 1979). Despite the plethora of in vitro studies on the effects of fluoride on the enzyme activity, there is a paucity of information concerning the in vivo m