Fluoride induces apoptosis and autophagy through the IL-17 signaling pathway in mice hepatocytes.
September 17, 2018
|
Archives of Toxicology
|
Zhao Y, Li Y, Wang J, Manthari RK, Wang J.
|
[Epub ahead of print]
Excerpts:
Apoptosis, characterized by nuclear fragmentation, chromatic condensation, and caspase activation, is a major molecular mechanism to eliminate cells (Oropesa-.vila et al. 2017 ). Apoptosis is observed widely in liver diseases (Cui et al. 2018 ; Potz et al. 2016 ). Fluoride, as an exogenous toxicant, has been reported to cause apoptosis in the liver (Khan et al. 2018 ). Song et al. (2015 ) reported that chronic fluoride exposure induced the liver apoptosis through activating the apopto