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Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Chronic Exposure to Sodium Fluoride Triggers Oxidative Biochemistry Misbalance in Mice: Effects on Peripheral Blood Circulation.

August 27, 2018 | Oxidative Medicine and Cellular Longevity | Miranda GHN, Gomes BAQ, Bittencourt LO, Aragão WAB, Nogueira LS, Dionizio AS, Buzalaf MAR, Monteiro MC, Lima RR. | Article ID 8379123
Excerpts: The fluoride exposure doses used in our study (10 and 50 mg/L) are often employed [32–34] and lead to a plasma fluoride levels in rodents similar to the ones found in humans consuming artificially fluoridated water or living in areas of endemic fluorosis, respectively [35]. It is important to note that F metabolism in rodents is 5–10 times faster than that in humans and the concentrations used in this investigation, 10 and 50 mg/L, correspond to 1-2 and 5–10 mg/L, respectively,

Fluoride induces apoptosis and autophagy through the IL-17 signaling pathway in mice hepatocytes.

September 17, 2018 | Archives of Toxicology | Zhao Y, Li Y, Wang J, Manthari RK, Wang J. | [Epub ahead of print]
Excerpts: Apoptosis, characterized by nuclear fragmentation, chromatic condensation, and caspase activation, is a major molecular mechanism to eliminate cells (Oropesa-.vila et al. 2017 ). Apoptosis is observed widely in liver diseases (Cui et al. 2018 ; Potz et al. 2016 ). Fluoride, as an exogenous toxicant, has been reported to cause apoptosis in the liver (Khan et al. 2018 ). Song et al. (2015 ) reported that chronic fluoride exposure induced the liver apoptosis through activating the apopto