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Transcriptional regulatory dynamics of the hypothalamic-pituitary-testicular axis in male mice exposed to fluoride.

Discussion The objective of this study was to investigate the effects of F oral exposure on T [testosterone] biosynthesis and the neuroendocrine regulation of the HPT axis in male mice. T is one of the endpoint parameters inHTP axis. In this study, reduced serum T concentration replicates our prior report of F-induced decrease in T in male mice (Huanget al., 2007), suggesting that animal model for F-induced dysfunction of gonadal hormone secretion was established. T, which is required for