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Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Fluoride Sources, Toxicity and Fluorosis Management Techniques – A Brief Review.

July 15, 2021 | Journal of Hazardous Materials Letters | Kashyap SJ, Sankannavar R, Madhu GM. | [Epub ahead of print]
Severe effects of fluoride on human health can be seen majorly in developing and underdeveloped countries. Among these countries, India is the most affected country, where there are many endemic fluorosis regions. India also has one of the largest fluorite deposits making its groundwater highly contaminated with fluoride. Most of the regions in Asia and Africa are prone to fluorosis based diseases. In Asia, India and China show the majority of cases. Whereas in the African continent, Tanzania is

Chemical pathology of homocysteine. IV. Excitotoxicity, oxidative stress, endothelial dysfunction, and inflammation.

July 2009 | Annals of Clinical Laboratory Science | McCully KS. | 39(3):219-32.
Fluoride is a toxic anion that stimulates oxygen consumption [64] and increases superoxide production in resting polymorphonuclear leukocytes [65]. Intracellular calcium ions are required for superoxide production by neutrophils during phagocytosis [66]. The effect of fluoride on superoxide production in neutrophils is reversible, causing superoxide production in the presence of fluoride, decreasing superoxide production when fluoride is removed, and restoring superoxide production when fluoride

Topical fluoride for caries prevention.

November 1, 2013 | Journal of the American Dental Association | Weyant RJ, Tracy SL, Anselmo T, Beltran-Aguilar ED, Donly KJ, Frese WA, Hujoel PP, Iafolla T, Kohn W, Kumar J, Levy SM, Tinanoff N, Wright JT, Zero D, Aravamudhan K, Frantsve-Hawley J, Meyer DM, American Dental Association Council on Scientific Affairs Expert Panel on Topical Fluoride Caries Preventive Agents. | 144(11):1279-1291.
The American Dental Association Council on Scientific Affairs Expert Panel on Topical Fluoride Caries Preventive Agents acknowledges the efforts of the following people and their commitment in helping complete this project: • Dr. Rocky Napier, Aiken, S.C., American Dental Association (ADA) Council on Access, Prevention, and Interprofessional Relations (CAPIR) liaison; • Ms. Jane McGinley, manager, Fluoridation and Preventive Health Activities, CAPIR, ADA, Chicago, ADA CAPIR staff l

Fluoride and Brain: A Review.

May 1, 2020 | International Journal of Pharmaceutical Sciences and Research | Ghosh S and Ghosh D. | 5: 2011-2017.
ABSTRACT: The mammalian central nervous system is composed of the brain and spinal cord. The brain is protected by the blood-brain barrier (BBB) that allows selective traffic of substances into the brain. Fluoride is a highly toxic and reactive element. We get exposed to fluoride due to its common use in toothpaste, dental gels, non-stick pans, razor blades, etc. Fluoride also enters our food chain through fishes that are cultivated in water bodies, which get contaminated with fluoride from

NTP Research Report on Systematic Literature Review on the Effects of Fluoride on Learning and Memory in Animal Studies: Research Report 1 [Internet]

July 2016 | | National Toxicology Program Research Report |
Background: Previous systematic reviews of epidemiology studies have found support for a geographical association between high levels of naturally occurring fluoride in water (>1.5 ppm) and lower IQ in children. Most of the evidence from humans is from fluoride-endemic regions having higher background levels of fluoride compared to the fluoride concentrations historically used in community water fluoridation programs (0.7–1.2 ppm). Confidence in this body of evidence is limited, prima