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Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Fluoride Induces Neuroinflammation and Alters Wnt Signaling Pathway in BV2 Microglial Cells.

August 2017 | Inflammation | Chen R, Zhao LD, Liu H, Li HH, Ren C, Zhang P, Guo KT, Zhang HX, Geng DQ, Zhang CY. | 40(4):1123-1130.
Fluoride exposure increases IL-1B and TNF-a production and changes the cellular oxidation and antioxidation status [5, 19]. Neuroinflammation seems to be an important mediator of the effects of fluoride. Neuroinflammation, which is mediated by microglia, contributes to most pathological neurologic processes, including CNS infections, ischemic stroke, neurodegenerative disease, and anesthetic neurotoxicity. Increased pro-inflammatory mediator production is thought to cause neuronal cell d

Fluoride: A review of use and effects on health.

April 2016 | Materia Socio-Medica | Kanduti D, Sterbenk P, Artnik B. | 28(2):133-7.
Introduction: Appropriate oral health care is fundamental for any individual’s health. Dental caries is still one of the major public health problems. The most effective way of caries prevention is the use of fluoride. Aim: The aim of our research was to review the literature about fluoride toxicity and to inform physicians, dentists and public health specialists whether fluoride use is expedient and safe. Methods: Data we used in our review were systematically searched

Low Prenatal Exposures to Fluoride: Are There Neurotoxic Risks for Children?

October 2017 | Environmental Health Perspectives | Julia R. Barrett | 125(10): 104002.
As a trace element, fluoride can help ward off dental cavities. Exceptionally high pre- and postnatal exposures, as seen in populations whose drinking water supplies are contaminated by natural fluoride sources, have been implicated in a number of adverse health effects.1,2,3,4 However, less is known about fluoride’s neurotoxic risks at lower levels of exposure. A new study in Environmental Health Perspectives examines risks of exposure to prenatal fluoride at concentrations typical of the g