Pathological findings of the present study also indicate toxicological magnification by fluoride in diabetic rats. Both diabetes and fluorosis are major disorders which affect several organ systems. It may be concluded from the present study that toxicity by fluoride is greater in diabetes.
NEWSPAPER REPORTS ON THIS ARTICLE:
The Wall Street Journal | October 28, 1992
By Marilyn Chase, Staff Reporter
Rat Studies Link Brain Cell Damage With Aluminum and Fluoride in Water
ANAHEIM, Calif. – A team of New York scientists said rat studies offer preliminary evidence that aluminum, when administered in drinking water, may be linked with behavior changes and damaged brain cells.The study, presented at the meeting here of the Society for Neuroscience, is the latest of several
"The histology of the cerebral hemisphere was altered by NaF and/or Arsenic trioxide [As2O3] treatment for 30 days, wherein the effect by As2O3 was greater than by NaF treatment. This result is in agreement with others... The reduced brain acetylcholinesterase (AChE) enzyme activity observed in the present study corroborates data of others in rats exposed for three months to arsenic trioxide and in the brain of NaF-treated mice and rats as compared to controls... The DNA and RNA levels in the ce
"In the present study, levels of glutathione and activities of catalase, GSH-PX, and SOD were significantly decreased, whereas lipid peroxide levels were enhanced in the brain of adult rats by treatment with NaF, As2O, or NaF + As2O3, in agreement with earlier reports."
